Lymphocyte Specific Protein Tyrosine Kinase p56(lckT-LymphocytesReceptors, Antigen, T-Cell淋巴细胞特异蛋白质酪氨酸激酶p56(LCKT淋巴细胞受体, 抗原, T细胞家庭The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively studied over the past 15 years. Animal models ...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene.5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.6.Aleshin, A, Finn, etal. SRC: a century of science br...
Src激酶家族成员 Src 家族是一类分子量为60 kDa的非受体酪氨酸激酶,目前在脊椎动物细胞中共发现9 种不同的家族成员,根据它们所处位置不同,可分为两类:广泛存在于组织细胞的c-Src、Fyn、c-Yes 和Yrk;仅存在于造血系统细胞的Blk、c-Fgr、Hck、Lck 和Lyn。Src激酶家族成员结构相似,从N端到C端,主要有四个结构...
The SRC Kinase family (SKF) is expressed in many malignant tumors and has wide range of refulatoru effects on tumor cells. Blk, Fgr, Hck, Lck, and Lyn are found primarily in hematopoietic cells, and Srm is found in keratinocytes. Frk occurs chiefly in bladder, brain, breast, colon, ...
Dasatinib（达沙替尼）基础信息 中文名：Src家族酪氨酸激酶抑制剂;SFK抑制剂;Bcl-Abl激酶抑制剂;达沙替尼 英文名：Dasatinib; Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor ;Src family tyrosine kinase inhibitor;SFK inhibitor;Bcl-Abl kinase inhibitor;BMS-354825 CAS号：302962-49-8 结构式：Cc1...
别名AG1879, AG-1879, AG 1879, PP2 cpd, Src family kinase inhibitor PP2 中文名N/A 化学式C15H16ClN5 分子量301.77 CAS号172889-27-9 纯度98% 溶剂/溶解度Water<1mg/ml; DMSO60mg/ml; Ethanol2mg/ml 溶液配制5mg加入1.66ml DMSO,或者每3.02mg加入1ml DMSO,配制成10mM溶液。SC1234-10mM用DMSO配制。
别名AG1879, AG-1879, AG 1879, PP2 cpd, Src family kinase inhibitor PP2 中文名N/A 化学式C15H16ClN5 分子量301.77 CAS号172889-27-9 纯度98% 溶剂/溶解度Water<1mg/ml; DMSO60mg/ml; Ethanol2mg/ml 溶液配制5mg加入1.66ml DMSO,或者每3.02mg加入1ml DMSO,配制成10mM溶液。SC1234-10mM用DMSO配制。
英文名:Dasatinib; Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor ;Src family tyrosine kinase inhibitor;SFK inhibitor;Bcl-Abl kinase inhibitor;BMS-354825 CAS号:302962-49-8 结构式:Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl 分子式:C22H26ClN7O2S 分子量:488.01 ...
Src family kinases, key regulators of signal transduction. Oncogene. 2004;23(48):7906-7909. 2.Roskoski R. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol Res. 2015;94:9-25. 3.Frame MC. Src in cancer: deregulation and consequences for cell behaviour...
Structure and regulation of Srcfamily kinases[J]. Oncogene. 5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25. 6.Aleshin, A, Finn, etal. SRC: a century of science brought to the clinic.[J]. ...