目前针对ESCC细胞中重要分子靶点的靶向抗癌药物的研发仍处于起步阶段。Src家族激酶(Src family kinases, SFKs)由多个成员组成,主要包括Src、Fyn、Yes、Blk、Fgr、Hck、 Lck和Lyn等。其中,酪氨酸激酶Src是最早发现的癌蛋白,且与多种肿瘤恶性进展、侵袭转移及药物耐药密切相关。然后,Src如何诱导ESCC恶性进展,靶向Src是否...
Src family kinases (SFKs) comprise a family of non-receptor tyrosine kinases that act as "signaling integrators," receiving upstream signaling inputs to effect an array of downstream cellular events such as proliferation, migration, invasion and survival. Several lines of evidence indicate that ...
1)Src family kinases (SFKs)Src-家族酪氨酸激酶 1.AimTo investigate the effects of inhibition of Src family kinases (SFKs) activation on connexin43 of gap junction in formation of cataract in vitro.研究背景前期研究发现在体外培养的鸡胚晶状体皮质性白内障模型中,抑制Src-家族酪氨酸激酶(SFK)活性能有效...
二、CLDN6信号通路 研究发现,CLDN6与Src家族酪氨酸激酶(Src family kinases,SFKs)相互作用,招募SFKs到Y196和Y200位点上,并使Y196/Y200位点发生磷酸化,SFKs-SH2与CLDN6上磷酸化的Y196/Y200的结合加强,从而完全激活SFKs,进而激活其下游信号通路。 Src是SFKs家族的核心成员,可作为膜受体与细胞质信号机制之间建立联...
Src Family Kinases(SFKs) 个人中心 普通会员 文献相关 全文翻译 会员中心 金币商城 科研服务 退出登录 Src Family Kinases(SFKs) 神经 关键词:神经临床研究术语酶 词汇介绍 拓展阅读 解析 family英 [ˈfæməli] 美 [ˈfæməli] 释义n. 家庭;家族;家属;子女;亲属;僚属...
摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉｎａｓｅｓꎬＳＦＫｓ)的核心成员.Ｓｒｃ广泛存在于人体细胞中ꎬ可调节细胞分裂㊁运动㊁黏附㊁血管生成和存活...
SFK (Src family kinase, SFK) belong to non-receptor tyrosine kniase. 以Src为代表的Src家族激酶(Src family kinase,SFK)是一类非受体型酪氨酸激酶。2) Src family tyrosine kinases Src家族蛋白激酶 例句>> 3) Src family kinases (SFKs) Src-家族酪氨酸激酶 1. AimTo investigate the effects of in...
Src family kinases: modulators of neurotransmitter receptor function and behaviordoi:10.1016/j.tins.2011.09.005Src family kinases (SFKs) are non-receptor-type protein tyrosine kinases that were originally identified as the products of proto-oncogenes and were subsequently implicated in the regulation of...
Src family kinases (SFKs) are one of the most studied groups of tyrosine kinases and can mediate a variety of signalling pathways. However, little is known about the expression of SFKs in human term placenta and their implication in trophoblast differentiation. Therefore, we examined the ...
Src family kinases (SFKs) are involved in both NMDA-mediated activation of TrkB- and TrkB-mediated tyrosine phosphorylation of NMDA receptors. We hypothesized that infusion of the SFK inhibitor, PP2, into the PrL cortex prior to a BDNF infusion, immediately after the end of the last cocaine ...