Definition Tyrosine kinase inhibitors ( TKIs ) are small molecules that bind to and inhibit the activity of tyrosine kinases. The latter are enzymes that catalyze the phosphorylation of a protein on the tyrosine residue using adenosine triphosphate as a substrate. The activities of tyrosine kinases ...
Dasatinib（达沙替尼）基础信息 中文名：Src家族酪氨酸激酶抑制剂;SFK抑制剂;Bcl-Abl激酶抑制剂;达沙替尼 英文名：Dasatinib; Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor ;Src family tyrosine kinase inhibitor;SFK inhibitor;Bcl-Abl kinase inhibitor;BMS-354825 CAS号：302962-49-8 结构式：Cc1...
英文名:Dasatinib; Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor ;Src family tyrosine kinase inhibitor;SFK inhibitor;Bcl-Abl kinase inhibitor;BMS-354825 CAS号:302962-49-8 结构式:Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl 分子式:C22H26ClN7O2S 分子量:488.01 ...
SFK, Src-family kinase; TK, tyrosine kinase. The modular structure of Src-kinases comprises a short N-terminal segment where a myristoylation (or more rarely palmitoylation) site occurs, which is sequentially followed by the so-called Unique domain, an SH3 domain, an SH2 domain, and the TK...
如细胞内钙离子浓度上调可直接通过钙调蛋白或蛋白激酶C(PKC)调节一些腺苷酸环化酶的活性,最终影响胞内cAMP的浓度。既往研究已证实在一些组织中Src家族酪氨酸激酶(Src family tyrosine kinase,SFK)的激活呈cAMP依赖或蛋白激酶A(PKA)依赖性,本研究旨在晶状体上皮中去探究是否存在cAMP依赖或者是PKA依赖的SFK的激活。
Src family tyrosine kinases inhibit single L-type: Ca2+ channel activity in human atrial myocytes. J Mol Cell Cardiol 2004;37:735-745.Schroder, F., Klein, G., Frank, T., Bastein, M., Indris, S., Karck, M., Drexler, H. and Wollert, K. C. (2004). Src family tyrosine kinases...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene.5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.6.Aleshin, A, Finn, etal. SRC: a century of science ...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene. 5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.
– Src family TKs inhibit single LTCC activity in human atrial myocytes via PKC-dependent, but PKA and phosphatase types I and IIa-independent, molecular pathways. 展开 关键词: channel Tyrosine kinases Human atrial cardiomyocytes DOI: 10.1016/j.yjmcc.2004.06.008 被引量: 43 ...
Src family kinases, key regulators of signal transduction. Oncogene. 2004;23(48):7906-7909. 2.Roskoski R. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol Res. 2015;94:9-25. 3.Frame MC. Src in cancer: deregulation and consequences for cell behaviour...