Definition Tyrosine kinase inhibitors ( TKIs ) are small molecules that bind to and inhibit the activity of tyrosine kinases. The latter are enzymes that catalyze the phosphorylation of a protein on the tyrosine residue using adenosine triphosphate as a substrate. The activities of tyrosine kinases ...
Dasatinib（达沙替尼）基础信息 中文名：Src家族酪氨酸激酶抑制剂;SFK抑制剂;Bcl-Abl激酶抑制剂;达沙替尼 英文名：Dasatinib; Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor ;Src family tyrosine kinase inhibitor;SFK inhibitor;Bcl-Abl kinase inhibitor;BMS-354825 CAS号：302962-49-8 结构式：Cc1...
SFK, Src-family kinase; TK, tyrosine kinase. The modular structure of Src-kinases comprises a short N-terminal segment where a myristoylation (or more rarely palmitoylation) site occurs, which is sequentially followed by the so-called Unique domain, an SH3 domain, an SH2 domain, and the TK...
既往研究已证实在一些组织中Src家族酪氨酸激酶(Src family tyrosine kinase,SFK)的激活呈cAMP依赖或蛋白激酶A(PKA)依赖性,本研究旨在晶状体上皮中去探究是否存在cAMP依赖或者是PKA依赖的SFK的激活。 本研究分离猪眼中的完整晶状体,经200mOsm的低渗Krebs溶液处理后,检测cAMP、Src家族蛋白磷酸化和钠/钾ATP酶的活性。研究...
Reprints and permissions © 2012 Springer Science+Business Media, LLC Cite this entry Sen, B., Johnson, F.M. (2012). c-Src Family of Tyrosine Kinases. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_54 ...
Dasatinib, Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor是非受体酪氨酸激酶 Abl 和 Src 以及 Src 家族其他成员的有效抑制剂。 它在亚纳摩尔浓度下有效,抑制 Src、Abl 和 Lck,IC50 值分别为 0.05、0.5 和 0.4 nM。在纳摩尔浓度下,达沙替尼还阻断其他几种受体和非受体酪氨酸激酶的活性, 加上...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene.5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.6.Aleshin, A, Finn, etal. SRC: a century of science ...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene. 5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.
Src family kinases, key regulators of signal transduction. Oncogene. 2004;23(48):7906-7909. 2.Roskoski R. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol Res. 2015;94:9-25. 3.Frame MC. Src in cancer: deregulation and consequences for cell behaviour...
5) Janus activated kinase JAK家族酪氨酸激酶6) Tec/Btk Family Tyrosine KinasesTec/Btk 家族的酪氨酸激酶补充资料:[3-(aminosulfonyl)-4-chloro-N-(2.3-dihydro-2-methyl-1H-indol-1-yl)benzamide] 分子式:C16H16ClN3O3S分子量:365.5CAS号:26807-65-8性质:暂无制备方法:暂无用途:用于轻、中度原发性...