The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1. Leuk Lymphoma. 2009; 50 :816–828.Scheele JS, Kolanczyk M, Gantert M, et al. The spt-ada- Gcn5-acetyltransferase complex interaction motif...
V. (2015). Spt-Ada-Gcn5-acetyltransferase (SAGA) complex in plants: genome wide identification, evolutionary conservation and functional determination. PLoS One 10:e0134709. doi: 10.1371/journal.pone.0134709.Srivastava R, Rai KM, Pandey B, Singh SP, Sawant SV (2015) Spt-Ada-Gcn5-...
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a critical regulator of gene expression and is highly conserved across species. Subunits of SAGA are arranged in discrete modules with lysine aceyltransferase and deubiquitinase activities housed separately. Mutation of the SAGA ...
Yeast (y) Gcn5 is part of two coactivator complexes, SAGA (Spt-Ada-Gcn5 acetyltransferase) and ADA (14). Mammalian GCN5 was also described to be part of two large HAT complex, called SAGA (15., 16.17) or ATAC (Ref. 18 and references therein). The mammalian SAGA complexes all contain...
Genome-widePhylogeneticCis-elementsGene expressionPineappleProtein complexes involved in epigenetic regulation can recruit transcriptional machinery to control gene expression. The Spt-Ada-Gcn5-acetyltransferase (SAGA) is a chromatin-modifying transcriptional co-activator with an independent role in regulating ...
Spt-Ada-Gcn5 acetyltransferase complex (SAGA) is an ATP-independent multifunctional chromatin remodeling complex that contributes to diverse transcriptional regulatory functions. As members of the core module in the SAGA complex in Saccharomyces cerevisiae , Ada1, together with Spt7 and...
The SAGA (Spt-Ada-Gcn5) histone acetyltransferase (HAT) complex of Saccharomyces cerevisiae is a multi-subunit co-factor for RNA polymerase II transcription. However, not all gene activation events require its intrinsic HAT activity. In addition, SAGA subunits can also restrict gene transcription. ...
Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1. J. Biol. Chem. 285:3850- 3856.Ellisdon AM, Jani D, Kohler A, Hurt E, Stewart M (2010) Structural basis for the interaction between yeast Spt-Ada-Gcn5 ...