Reports that GCN5-related histone acetyltransferase (HAT) belong to a far more extensive superfamily of both known and putative N-acetyltransferases (NAT). Two regions of sequence similarity; Functional significance of the conserved residues in the two regions; Limited analysis employed in order to ...
General control non-repressible 5 (GCN5)-relatedN-acetyltransferases (GNAT) catalyze the transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates and are widely distributed in all domains of life. This review of the currently available data acquired on GNAT...
The C-terminal region of Ngs1 is essential for growth on GlcNAc and contains a weak sequence homology to the NAT domain of the GCN5-relatedN-acetyltransferase (GNAT) family31,32. GNAT members are known to share weak similarities by sequence alignment, but they all have a universally conserved...
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Cell. 1998; 94:439-449. [PubMed: 9727487]Wolf, E., Vassilev, A., Makino, Y., Sali, A., Nakatani, Y., & Burley, S. K. (1998). Crystal structure of a GCN5-related N-...
Gcn5‐related N‐acetyltransferaseproduct‐based transition‐state modelingradical‐mediated bisubstrateGcn5‐related N‐acetyltransferases (GNATs) are found in all kingdoms of life and catalyze important acyl transfer reactions in diverse cellular processes. While many 3D structures of GNATs have been ...
2016. N-acetylglucosamine sensing by a GCN5- related N-acetyltransferase induces transcription via chromatin his- tone acetylation in fungi. Nat Commun 7:12916. https://doi.org/10 .1038/ncomms12916.Su C, Lu Y, Liu H. N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase ...
Acetylating Polymyxin Antibiotics: Clues Toward Substrate Specificity of PA3944 Gcn5‐related N‐acetyltransferase of Unknown FunctionAlthough Gcn5-related N-acetyltransferases (GNATs) have been studied for several decades in the context of aminoglycoside resistance and histone acetylation, the majority of ...
1998. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell. 94(4):427-438.Dutnall, R.N., Tafrov, S.T., Sternglanz, R., and Ramakrishnan, V. (1998). Structure of the histone acetyltransferase Hat1: a paradigm for the ...
Zhen QinYibei XiaoXinbin YangJeroen R. MestersShaoqing YangZhengqiang JiangA unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3β-N-acetylglucosaminidase.. Qin Z,Xiao Y,Yang X,et al. Scientific Reports . 2015...
Eukaryotic domain of unknown function DUF738 belongs to Gcn5-related N-acetyltransferase superfamily. Cell Cycle. 2006; 5:2927-2930. [PubMed: 17172875]Steczkiewicz K, Kinch L, Grishin NV, Rychlewski L, Ginalski K. Eukaryotic domain of unknown function DUF738 belongs to Gcn5-related N-...