Molecular Sciences Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)GNATacetyltransferasecrystal structure AIMS Ud-Din,A Tikhomirova - 《International Journal of Molecular Sciences》 被引量: 0发表: 2016年 GCN5-Related N-Acetyltransferases: A Structural Overview to in the lite...
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Cell. 1998; 94:439-449. [PubMed: 9727487]Wolf, E., Vassilev, A., Makino, Y., Sali, A., Nakatani, Y., & Burley, S. K. (1998). Crystal structure of a GCN5-related N-...
The C-terminal region of Ngs1 is essential for growth on GlcNAc and contains a weak sequence homology to the NAT domain of the GCN5-relatedN-acetyltransferase (GNAT) family31,32. GNAT members are known to share weak similarities by sequence alignment, but they all have a universally conserved...
Gcn5‐related N‐acetyltransferaseproduct‐based transition‐state modelingradical‐mediated bisubstrateGcn5‐related N‐acetyltransferases (GNATs) are found in all kingdoms of life and catalyze important acyl transfer reactions in diverse cellular processes. While many 3D structures of GNATs have been ...
Acetylating Polymyxin Antibiotics: Clues Toward Substrate Specificity of PA3944 Gcn5‐related N‐acetyltransferase of Unknown FunctionAlthough Gcn5-related N-acetyltransferases (GNATs) have been studied for several decades in the context of aminoglycoside resistance and histone acetylation, the majority of ...
The aminoglycoside 6'-N-acetyltransferase AAC(6')-Ii from Enterococcus faecium is an important microbial resistance determinant and a member of the GCNS-related N-acetyltransferase (GNAT) superfamily. We report here the further characterization of this enzyme in terms of the kinetic mechanism of ...
Angus-Hill ML , Dutnall RN , Tafrov ST , Sternglanz R and Ramakrishnan V ( 1999 ) Crystal structure of the histone acetyltransferase Hpa2: a tetrameric member of the Gcn5-related N -acetyltransferase superfamily . J Mol Biol , 294 , 1311 – 1325 ....