This review covers the three-dimensional structures of members of one of these superfamilies, now referred to in the literature as the GCN5-related N-acetyltransferases (GNAT), reflecting the importance of one functional category, the histone acetyltransferases. Despite the diversity of substrate ...
Structural studies of members of the superfamily of GCN5-related N-acetyltransferases (GNATs) provided the first atomic resolution structures of HATs for conserved mechanisms of acetyl-CoA interaction11. Enzymatic activities of HATs are regulated by phosphorylation, interaction with other proteins10, and...
Structural studies of members of the superfamily of GCN5-related N-acetyltransferases (GNATs) provided the first atomic resolution structures of HATs for conserved mechanisms of acetyl-CoA interaction11. Enzymatic activities of HATs are regulated by phosphorylation, interaction with other proteins10, and...
Figure 1. GCN5-Related N-acetyltransferases and Aminoglycoside Substrate (A) Structure-based sequence alignment of GCN5-related N-acetyltransferases. The secondary structural elements were assigned from the X-ray structure (Kabsch and Sander 1983), and the locations of GNAT motifs C, D, A, and ...
related N-acetyltransferase (GNAT) superfamily of N-acetyltransferases involved in histone acetylation.1 Gcn5 and PCAF contain a highly conserved central core with divergent N- and C-terminal ends.2 Gcn5/PCAF are enzymatic subunits that exist in a mutually exclusive manner as part of the ...
DNA-Binding Proteins, Dimerization, Fungal Proteins, Histone Acetyltransferases, Histones, Models, Molecular, Molecular Sequence Data, Multigene Family, Protein Folding, Protein Kinases, Protein Structure, Quaternary, Saccharomyces cerevisiae, enzymology, Saccharomyces cerevisiae Proteins, Structure-Activity Relatio...
Nuclear acetyltransferases are involved in a wide variety of cellular processes, including transcription regulation, chromatin structure, DNA repair, cell cycle control, and many others. However, it remains unclear how acetyltransferase enzymes are regulated and how such regulation controls the acetylation ...
These findings strongly support the notion that GCN5 protein is a key N-Myc transcriptional cofactor in NSC, but are also consistent with recruitment of GCN5 by other transcription factors and the use by N-Myc of other histone acetyltransferases. Putative N-Myc/GCN5 coregulated transcriptional ...
-中文论著摘要・ 正常妊娠及胚胎停止发育绒毛中 GCN5、P300/CBP的表达差异以及与IGF2的关系 目的胚胎停止发育是指妊娠早期胚胎因某种原因发育停止致胚胎死亡,最终流产。 是孕早期常见的病理妊娠之一。对育龄期妇女的身心健康造成很大危害。造成胚 胎停止发育的原因很多,但发病机制目前尚未完全明确。 近年来研究发现正常...
5C-D). As a member of lysine acetyltransferases, the combination of GCN5 and TAK1 prompted us to detect whether GCN5 could affect the acetylation modification level of TAK1, the results showed that the level of acetylated TAK1 was not influenced by MB3 treatment (Supplementary Fig. 5E), ...