Here, we reported that in colorectal cancer cells the expression of NAT10 (N-acetyltransferase 10) could mediate MN formation through DNA replication and NAT10-positive MN could activate SASP by binding to cGAS. The chemical inhibition of NAT10 by Remodelin or genomic depletion could markedly ...
Nα-acetyltransferase 10 protein (Naa10p) is known as the catalytic subunit of N-terminal acetyltransferases A (NatA) complex, associating with Naa15p to acetylate N-termini of the human proteome. Recent investigations have unveiled additional functions for Naa10p, encompassing lysine ε-acetylation...
NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma. In this study, we evaluated membranous staining of NAT10 in colorectal carcinoma and its clinical implications, and explored the mechanism of regulation of NAT10 redistribution.The ...
50864-40-9 英文名: gentamicin 2'-N-acetyltransferase 英文别名: gentamicin 2'-N-acetyltransferase 中文名: gentamicin 2'-N-acetyltransferase 中文别名: CBNumber: CB71309110 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商2
Fig. 1: Lack of NatA activity (naa10Δ) causes the downregulation of mitochondrial and ribosomal proteins. AScheme of the performed proteome profiling experiments. Yeast were harvested at active growth phase and lysates were digested using the proteome capture aggregation method (PAC) prior High-pH...
被引量: 10发表: 2004年 Effect ofSULT1A1 andNAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by SULT1A1. A genetic polymorphism ... EW ...
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Indeed, by using an independent quantitative assay, hNaa10p strongly acetylated peptides representing the N termini of both γ- and β-actin, and only to a lesser extent, its previously characterized substrate motifs. The immunoprecipitated NatA complex also acetylated the actin N termini ...
Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-transl... Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p ...