他们的最新研究“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”已于著名期刊《Science》上发表。作者发现,由 CXCL9 和 SPP1 这两个基因的表达所定义的巨噬细胞极性的变化是肿瘤微环境的一个简单而关键的特征。CXCL9:SPP1的比例可以描述癌症中抗肿瘤免疫细...
5. 肿瘤相关巨噬细胞可能促进癌症细胞的上皮-间充质转移 为了研究巨噬细胞通过常见的L–R对(TNFSF12–TNFRSF12A和SPP1–CD44)对肿瘤细胞的特异性影响,我们进一步计算了癌症细胞中TNFRSF12 A或CD44表达与标志性特征评分之间的相关性。结果显示,血管生成、糖酵解和EMT是与CD44表达最相关的生物学过程,而在癌症细胞...
Hu M ,et al.Characterizing Intercellular Communication of Pan-Cancer Reveals SPP1+ Tumor-Associated Macrophage Expanded in Hypoxia and Promoting Cancer Malignancy Through Single-Cell RNA-Seq Data[J].Frontiers in cell and developmental biology, 2021, 9:749210.DOI:10.3389/fcell.2021.749210....
Chen Z , Hu M ,et al.Characterizing Intercellular Communication of Pan-Cancer Reveals SPP1+ Tumor-Associated Macrophage Expanded in Hypoxia and Promoting Cancer Malignancy Through Single-Cell RNA-Seq Data[J].Frontiers in cell and developmental biology, 2021, 9:749210.DOI:10.3389/fcell.2021.749210...
Consistently with these findings, our results indicated that compared to the dMMR group, both SPP1 + macrophage and FAP + fibroblast displayed enhanced interactions with ECM remodeling-related ligands within the TiME of pMMR GC patients; moreover, both cell types exhibited characteristics ...
The present study demonstrated that secreted phosphoprotein 1 (SPP1) was aberrantly highly expressed in the lung tissue of patients with IPF and was significantly positively associated with macrophage and Tcell activity. Cell localization studies revealed that SPP1 was primarily over...
Two-sided unpaired limma moderated t test. B Immunoblot analysis and real-time qPCR analysis were used to measure SPP1 protein and mRNA levels, in SPP1-OE macrophages, respectively. C Schematic diagram of tumor cell culture in macrophage supernatant or coculture with macrophages for in vitro ...
Consistently with these findings, our results indicated that compared to the dMMR group, both SPP1 + macrophage and FAP + fibroblast displayed enhanced interactions with ECM remodeling-related ligands within the TiME of pMMR GC patients; moreover, both cell types exhibited characteristics ...
(Fig.4aand Supplementary Fig.2c), which was shown to activate M1-like TAMs and promote the malignant migration of cancer58. In addition,VCAN+macrophages (n = 600) were identified by high expression ofVCAN, and another macrophage subtype,C1QC+MRC1−macrophages (n = 1480), were ...
This study delved into the molecular mechanisms underlying mechanical stress-induced intervertebral disc degeneration (msi-IDD) through single-cell and hig