Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies. Trends Immunol. 44, 971–985. https://doi.org/10.1016/j.it.2023.10.007 (2023). Article CAS PubMed Google Scholar Liu, Y. et al. Identification of a tumour immune barrier in the HCC ...
C Schematic diagram of tumor cell culture in macrophage supernatant or coculture with macrophages for in vitro experiments. D, E The colony-forming ability of HN6 (D) and CAL27 (E) cells was increased when they were cocultured with SPP1-OE macrophages. F, G The migration ability of HN6...
综上,TAM_SPP1和MMP9是HCC潜在的预后生物标志物和治疗靶点,本研究可能为HCC患者的临床治疗提供新的见解。 参考文献 Yang CL, Song R, Xiang BD, et al. Integrating single-cell and bulk RNA sequencing reveals CK19 + cancer stem cells and their specific SPP1 + tumor-associated macrophage ni...
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies. Trends Immunol. 44, 971–985. https://doi.org/10.1016/j.it.2023.10.007 (2023). Article CAS PubMed Google Scholar Liu, Y. et al. Identification of a tumour immune barrier in the HCC ...
本研究通过整合单细胞和Bulk RNA测序数据,来探索人类乙型肝炎病毒(HBV)相关的肝细胞癌(HCC)中CK19阳性的肿瘤干细胞(CK19+ CSCs)的异质性和干性特征,及其特异性富集的TAM_SPP1亚群的促肿瘤分子机制,为HCC提供新的潜在治疗靶点。 新格元在该研究中提供了GEXSCOPE®单细胞转录组测序。
In hepatocellular carcinoma (HCC), classical cancer stem cells (CSC) markers were shared by normal stem cells, targeting which may hinder hepatic regeneration and cause liver failure. Additionally, the spatial structure of CSC still remained elusive. To address these limit...
Macrophage phenotypes were determined using qRT‒PCR and immunohistochemical staining. RNA sequencing was performed to elucidate the mechanism. Results Increasing expression of SPP1 correlated with M2-like TAM accumulation in ESCC, and they both predicted poor prognosis in the ESCC cohort. Knockdown of...
摘要 目的探讨分泌性磷蛋白1(SPP1)及程序性死亡因子配体-1(PD-L1)在肝细胞癌(HCC)患者中的表达及与M2巨噬细胞的相关性以及对预后的影响。方法采用免疫组化法检测81例肝癌患者中SPP1、PD-L1以及CD163(...展开更多 Objective To evaluate the expression of programmed death receptor ligand-1(SPP1),programmed...
Tumor-associated macrophageSPP1HeterogeneityMatrix metalloproteinase 9VEGFA signalPurpose Cytokeratin 19-positive cancer stem cells (CK19+CSCs) and their tumor-associated macrophages (TAMs) have not been fully explored yet in the hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). ...
1) Macrophage Regulation in IDD: SPP1 activates the PERK/ATF4/IL-10 signaling axis in macrophages, increasing IL-10 production, essential for inhibiting msi-IDD progression. 2) Effective Intervention: Inhibition of SPP1 in macrophages shows potential for therapeutic intervention, significantly mitigating...