In this study, through profiling so far the largest pool of single cells in planarian, we established a comprehensive spatiotemporal transcriptomic atlas for describing the dynamic difference in both cell types and gene expression during regeneration. Based on this atlas, the 3D distribution of the ...
Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regenerationREGENERATION (Biology)GENE regulatory networksTRANSCRIPTOMESGENE expressionFUNCTIONAL analysisWhole-body regeneration of planarians is a natural wonder but how it occurs remains elusive. It requires ...
et al. Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord. Development 146, dev173807 (2019). Lohoff, T. et al. Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis. Nat. Biotechnol. 40, 74...
Moreover, interspecies comparison reveals conserved root cell types and core markers in response to HS in plants, which are experimentally validated. These results provide a universal atlas for unraveling the transcriptional programs that specify and maintain the cell identity of maize roots in response...
Allen Brain Atlas Common Coordinate Framework (CCFv3) (Additional file 1: Table S2a; Methods; Additional File 2). Human tumor programs were most diverse in the core, with three to four discernable programs per spot in high-density regions and one to two programs present per spot in lower-...
. The resulting composite structure of DNA and hydrogel is visualized as blue undulating lines. Each amplicon, carrying a unique five-base barcode, undergoes sequential decoding through a six-stage process known as SEDAL fluorescence. This multiplexed RNA quantification approach precisely reveals gene ...
Transcriptomic profiling of the tumor microenvironment reveals distinct subgroups of clear cell renal cell cancer: data from a randomized phase III trial. Cancer Discov. 2019;9:510–25. Article CAS Google Scholar Horn S, Leonardelli S, Sucker A, Schadendorf D, Griewank KG, Paschen A. Tumor ...
transcriptomic information in TCGA-CRC. The results revealed that CC has a significant impact on the TME. We identified leiomodin 1 (LMOD1)—a potential regulator of the CC phenotype with biphasic features of both GJs and TJs. It was confirmed that LMOD1 is a factor in poor immune ...
S3). Furthermore, extracting measurements of our neuron-enriched proteins from the human proteome map resource (www.humanproteomemap.org) reveals elevated values in either fetal or adult brain compared with other human tissues (supplemental Fig. S4). This finding indicates that proteomic dynamics ...
Atlas of the aging mouse brain reveals white matter as vulnerable foci Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotem... O Hahn,AG Foltz,Micaiah AtkinsBlen KedirPatricia Moran-Losadalan ...