TranscriptomeEncéfaloHombreBrain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and ...
In this study, we used Slide-seq, a technology that generates transcriptome-wide gene expression data at 10-µm spatial resolution33,39, to build maps of whole embryos during early mouse organogenesis. Our data enabled the exploration of spatial gene expression patterns, cell state distributions...
In this study, by using integrated single-cell and spatial transcriptomics, we created a high-resolution, spatially resolved transcriptome map of reovirus-induced myocarditis in neonatal mouse hearts. We assayed hearts collected at three timepoints after infection and studied the temporal, spatial and ...
Developmental and zone-dependent plasticity of the seminal root transcriptome upon water deficitWe surveyed the transcriptomic dynamics of barley seminal root zones subjected to water deficit (-0.8 MPa) and to control conditions for 6 h, 24 h and 48 h (see methods), hence before phenotypic change...
Based on single-cell transcriptome similarity, our analyses indicate that the developmental stages of E15.5 to P2 mice are similar to the human developmental stages of GW12-27, indicating that the human cerebellum develops much earlier than the mouse cerebellum; however, the overall cell type ...
Our study provides the first extensive spatiotemporal transcriptome study in the mare covering different time points during the window of MRP. The approach used in our study to unravel unknown MRP signaling in the mare was based mainly on three points: (i) up to date, it is not completely ...
Using the tomato cultivar 'Moneymaker', we analyzed the transcriptome of the ovule and the ovary wall/pericarp dissected from four different stages of the early developing fruits by stereoscope. These datasets give us the whole picture about the spatial and temporal signal distribution in early ...
中国科学家解码人脑多区域时空发育奥秘上篇 | 2023年12月,中国科学院动物研究所焦建伟团队、广州国家实验室董骥团队、北京大学杜鹏团队和北京大学靳蕾团队在Cell(IF=64.5)发表题为Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain的文章。通过单细胞(scRNA-seq)和时空转...
Whole-transcriptome sequencing SCNA: Somatic copy number alterations LOH: Loss of heterozygosity ITH: Intratumoral heterogeneity TCR: T cell receptor ccRCC: Clear cell renal cell carcinoma TME: Tumor microenvironment ICI: Immune checkpoint inhibitor TKI: Tyrosine kinase inhibitor HERV: Human...
Total 94 RNA-seq datasets obtained from public resources represent the comprehensive transcriptome data across four developmental stages (V12, V14, V18, and R1) from three major maize tissues (ear, tassel, and leaf) that were subjected to drought stress and well-watered conditions [28]. Approxim...