TranscriptomeEncéfaloHombreBrain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and ...
In this study, we used Slide-seq, a technology that generates transcriptome-wide gene expression data at 10-µm spatial resolution33,39, to build maps of whole embryos during early mouse organogenesis. Our data enabled the exploration of spatial gene expression patterns, cell state distributions...
In this study, by using integrated single-cell and spatial transcriptomics, we created a high-resolution, spatially resolved transcriptome map of reovirus-induced myocarditis in neonatal mouse hearts. We assayed hearts collected at three timepoints after infection and studied the temporal, spatial and ...
Transcriptome analysis revealed the drought-responsive genes in Tibetan hulless barley. BMC Genomics. 2016;17:386. https://doi.org/10.1186/s12864-016-2685-3. Article CAS PubMed PubMed Central Google Scholar Adda A, Sahnoune M, Kaid-Harch M, Merah O. Impact of water deficit intensity on...
Spatiotemporal transcriptome provides insights into early fruit development of tomato (Solanum lycopersicum) 来自 EBSCO 喜欢 0 阅读量: 209 作者:S Zhang,M Xu,Z Qiu,K Wang,Y Du,L Gu,X Cui 摘要: Early fruit development is crucial for crop production in tomato. After fertilization, the ovary ...
Hence, we used the Glmnet algorithm31,32 to age match the developing cerebellum between mice and humans based on single-cell transcriptome profiles. We found that the human GW12-GW27 cerebellum was comparable to that of mice from embryonic Day 15 (E15) to postnatal Day 2 (P2) (Fig. 5a...
Our study provides the first extensive spatiotemporal transcriptome study in the mare covering different time points during the window of MRP. The approach used in our study to unravel unknown MRP signaling in the mare was based mainly on three points: (i) up to date, it is not completely ...
中国科学家解码人脑多区域时空发育奥秘上篇 | 2023年12月,中国科学院动物研究所焦建伟团队、广州国家实验室董骥团队、北京大学杜鹏团队和北京大学靳蕾团队在Cell(IF=64.5)发表题为Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain的文章。通过单细胞(scRNA-seq)和时空转...
[176] employed spatial transcriptomics combined with single-cell sequencing to map the spatiotemporal transcriptome of the aging mouse brain comprehensively. Their detailed investigation revealed pronounced regional disparities in glial cell senescence, particularly within cerebral white matter glial cells, and...
progenitor cell clusters were located between differentiated cells and neoblast clusters (Supplementary Fig.6d). Moreover, we identified eight subtypes of muscle cells (Fig.3a) and several markers (Fig.3b, c). Interestingly, based on the marker gene expression in spatial transcriptome data, we ...