An increasing number of commercially available platforms now facilitate spatially resolved, high-dimensional assessment of gene transcription, known as 'spatial transcriptomics'. Here, we introduce different classes of method, which either record the locations of hybridized mRNA molecules in tissue, image ...
spatial transcriptomics’s advantages are two-fold. Firstly, it removes the need for tissue dissociation of delicate neurons. Secondly, it preserves the spatial context of cells. One study employedSpatial Transcriptomicsto determine gene modules expressed in ...
Recent advances in spatial omics have expanded the spectrum of profiled molecular categories beyond transcriptomics. However, many of these technologies are constrained by limited spatial resolution, hindering our ability to deeply characterize intricate
Introduction White adipose tissue (WAT) is a uniquely plastic organ that can expand or shrink in response to caloric supply and demand. The ability to function across pronounced variations in tissue mass is governed by a plethora of resident and recruited cell types1. Disturbed WAT remodeling lead...
Introduction Transcriptomicsis used to identify the transcriptional activity that is present in cells and tissues (Hegde et al., 2003). The transcriptome consists of the coding and ncRNAs that are transcribed in cells, tissues, or organs during normal physiological or pathological conditions (Assis et...
The same study noted that T cells from TLS-negative tumors had a more exhausted phenotype, expressing higher PD1 and Tim3 [26]. As noted above, spatialtranscriptomicsandproteomicstechnologies (Table 2) could be used to characterize the CD8+T cells surrounding TLS and compare them to those locat...
Introduction Trajectory inference (TI) provides important insights in understanding cell development and biological process. However, the integration of transcriptomic profiles and spatial locations to organize spatiotemporal cell orders is currently remaining challenges. Here we introduce spaTrack, which effect...
Single Cell and Spatial Omics Single cell transcriptomics technology have been scaled up very nicely over the past ten years Spatial informatics field is lacking in innovations Can get a terabyte worth of data from analysis of one slide 11:25-11:35 PRODUCT PRESENTATION 204C ...
1Introduction The examination of how various drugs interact with the body and how a medication needs to act on the body to have a therapeutic impact is known as drug discovery. Drug discovery strategy constitutes from different approaches as physiology-based and target based. This strategy is base...
Hepatocellular carcinoma (HCC) often presents with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge in personalized medicine. The emergence of spatial transcriptomics (ST