Abstract 01: Spatial Transcriptomics Reveals How Smooth Muscle Cells Transform to Renin-Expressing Cells During Homeostatic Challengedoi:10.1161/hyp.81.suppl_1.01Renin-Aldosterone-Angiotensin (Raa)GenomicsCell signalingIntroduction:Juxtaglomerular (JG) cells sense changes in blood pressure through communication...
Fan noted that analyzing gene expression is currently the centerpiece of spatial. One reason for that, Banovich noted, is the digitization of the signal. The analysis of data in a way that uses the existing genomic tool set seems to be what allowed spatial biology—particularly spatial transcrip...
CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics. Nat. Protoc. https://doi.org/10.1038/s41596-024-01045-4 (2024). Yang, M. et al. Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells. Cell 186, 4271–4288 (2023). ...
Spatial transcriptomics—visualizing gene expression at different tumor locations at a single-cell resolution—brings a spatial dimension to these efforts, facilitating the understanding of interactions among cell subtypes to find novel targets for cancer therapy discovery....
Integration of transcriptomics and MERFISH, a spatially resolved transcriptomic method, reveals the spatial organization of mouse motor cortex cell types (Zhang et al., 2021a). A major finding of the study is that in addition to the laminar distribution of glutamatergic neuron subclasses as expected...
The immune system is a complex network of specialized cells that work in concert to protect against invading pathogens and tissue damage. Imbalances in this network often result in excessive or absent immune responses leading to allergies, autoimmune dis
(TMB) and augmented immune infiltration, has attracted considerable attention [20]. High TMB has been associated with better response and survival to the ICB therapy [21]. However, low TMB does not necessarily imply a lack of response to the treatment of ICB [22]. While TMB is considered ...
Consequently, to better understand the spatial resolution of bacteria, multiple questions need to be addressed in the future: Which ecological abiotic niche factors (physical and chemical factors) support bacteria–tumor co-localization? To what extent does host–microbe mutualism (bilateral cross-...
This scenario may be applicable if resistance to one parasite does not correlate with resistance to another [61]. Second, a diverse parasitic assembly could select a more general resistance mechanism, which in itself is more costly (but potentially less effective against a specific parasite) than ...
transcriptomics and proteomics, it was revealed that the AMG and PMG venom is generated following harassment and electrostimulation, respectively [88]. Specifically, the venom specific to the PMG potently paralyzes and kills prey insects, while the AMG-specific venom alternatively does not paralyze ...