Spatial transcriptomics combines high-plex quantification with the spatial resolution of immunohistochemistry. This technology classifies tissue based on total mRNA within the morphological context of FFPE or frozen tissues. Spatial expression mapping is a powerful tool for examining cellular interactions, ...
Finally, we perform the data integration to predict the cell type composition within the determined spatial domains.Spatial transcriptomics analysis is a powerful method that has highly improved critical aspects of cancer research, such as the characterization of tumor microenvironment, the discovery of ...
Spatial transcriptomics produces high-dimensional gene expression measurements with spatial context. Obtaining a biologically meaningful low-dimensional representation of such data is crucial for effective interpretation and downstream analysis. Here, we
In recent years, there has been a rapid development in spatial transcriptomics data analysis techniques. From data preprocessing to the identification of spatially variable genes, clustering analysis, and downstream functional analysis, these steps can now be accomplished through a plethora of computational...
Discover what's possible with spatial transcriptomics, including the additional depth it can add to single cell research projects, through these high-impact publications. Human liver cancer; Visium Spatial Zhang S, et al. Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advan...
Here ‘LR’ method in Seurat FindAllMarkers was used for conducting this analysis. Sample sizes and statistical tests for all experiments in this manuscript were determined based on established literature in the field from us and others who have reported single-cell transcriptomics, viral tracing ...
Spatial transcriptomics is a technology that integrates imaging, biomarkers analysis, sequencing, and bioinformatics to precisely locate gene expression within tissue slices. It reveals the spatial distribution of diverse cell types in tissues, investigates the interactions between cell populations, and constr...
Spatial transcriptomics, commercialized as Visium Spatial Gene Expression, is a molecular profiling method that enables scientists to map whole transcriptome gene activity across an entire tissue section alongside H&E morphological imaging.The next evolution of this platform—powered by Visium CytAssist, ...
A Complete Spatial Transcriptomics Solution Features of the MERSCOPE® Ultra Platform The Applications The MERSCOPE® Ultra Platform Position yourself at the forefront of scientific discovery with the MERSCOPE® Ultra Platform, the industry’s high plex, in situ single-cell spatial genomics solutio...
Gene set variation analysis HPV: Human papillomavirus LE: Leading edge NOR: Normal tissue PCA: Principal component analysis PPI: Protein-protein interaction RNA-Seq: RNA sequencing scRNA-seq: Single-cell RNA sequencing ST: Spatial transcriptomics TC: Tumor core TCGA: The Cancer Genome...