[2]Li Q, Chen K, Zhang T, et al. Understanding sorafenib-induced ferroptosis and resistance mechanisms: Implications for cancer therapy. Eur J Pharmacol. 2023;955:175913. doi:10.1016/j.ejphar.2023.175913 [3]Wei S, Wei F, Li M, et al. Target immune components to circumvent sorafenib resi...
Sorafenib,which inhibits multiple kinases,is an effective frontline therapy for hepatocellular carcinoma(HCC).Ferroptosis is a form of iron-dependent programmed cell death regulated by lipid peroxidation,which can be induced by sorafenib treatment.Oncoprotein hepatitis B X-interacting protein(HBXIP)...
Sorafenib, which inhibits multiple kinases, is an effective frontline therapy for hepatocellular carcinoma (HCC). Ferroptosis is a form of iron-dependent programmed cell death regulated by lipid peroxidation, which can be induced by sorafenib treatment. Oncoprotein hepatitis B X-interacting protein (HBXI...
SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase Feng-li Xu, Xiao-hong Wu, Chang Chen, Kai Wang, Lu-yi Huang, Jie Xia, Yi Liu, Xue-feng Shan & Ni Tang Cell Death & Disease volume 14, Article number: 22 (2023)...
The results showed that blocking FASN expression promoted sorafenib-induced ferroptosis via downregulation of SLC7A11 expression, which reversed treatment resistance of HCC cells. Notably, we also found that orlistat, an inhibitor of FASN [18], enhanced the sensitivity of resistant cells to sorafenib ...
(23.5%,P= 0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have ...
Amy induces apoptosis and ameliorates the Sor-induced necrosis in HepG2 cells The loss in cell viability could be brought about by an apoptotic response to Amy and Sor, as suggested by the MTT assay and microscopic inspection. To further establish the cell death process (apoptosis vs. necrosis...
Noticeably, in 3D and 2D-grown HCC cells, miR-494 induced HIF-1A stabilization suggesting a metabolic advantage in large–size 3D structure formations (Fig. 2F, S3I). In line, AM-494 transfection decreased HIF-1A protein levels in HepG2 cells and miRNA-overexpressing Huh-7 cells (Fig. ...
(23.5%,P= 0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have ...
SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase ArticleOpen access12 January 2023 Introduction Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Hepatic cancer is sixth in terms of incidence and second in ...