Iron metabolism and ferroptosis in health and diseases: The crucial role of mitochondria in metabolically active tissuesIron is essential in various physiological processes, but its accumulation leads to oxidative stress and cell damage, thus iron homeostasis has to be tightly regulated. Ferroptosis is ...
Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ...
在2021年9月份发表的文章《Identification of Iron Metabolism-Related Genes as Prognostic Indicators for Lower-Grade Glioma》中,作者通过GSEA网站查找了约16个基因集,连同2篇文献,找到527个铁代谢相关基因。 图4. 527个铁代谢相关基因来源 2022年7月份的文章《Hub Genes, Diagnostic Model, and Predicted Drugs Re...
Iron metabolism consists of the absorption of dietary iron from the gastrointestinal tract, transport in the blood, storage in the liver and macrophages, and utilization in the cells requiring synthesis of iron-containing proteins (e.g., hemoglobin in erythroblasts). Iron deficiency causes anemia ...
Ferroptosis is a recently defined form of programmed cell death that uniquely links elements such as iron, selenium, amino acids, lipids, and redox chemistry in cell metabolism into a cohesive network. Both in vitro and in vivo experiments support the regulation of ferroptosis in various immune ce...
in AD. However, the underlying mechanisms have not been fully elucidated. This article reviews the potential role of ferroptosis in AD, the involvement of ferroptosis in the pathological progression of AD through the mechanisms of iron metabolism, lipid metabolism, and redox homeostasis, as well as...
Considering the crucial effects of ferroptosis and iron metabolism on the occurrence and progression of hepatocellular carcinoma (HCC), in this study, we perfordoi:10.2139/ssrn.3521399Tang, BufuZhu, JinyuLi, JieFan, KaiGao, YangCheng, Shimiao...
fast-moving field. Wang’s earlier research, including at Harvard Medical School, in the laboratory of Nancy Andrews, focused on iron metabolism. This prepared the ground for understanding the cellular mechanisms that drive ...
Ferroptosis is a recently defined form of programmed cell death that uniquely links elements such as iron, selenium, amino acids, lipids, and redox chemistry in cell metabolism into a cohesive network. Both in vitro and in vivo experiments support the regulation of ferroptosis in various immune ce...
iron metabolism [21,22]. These natural compounds may provide ligands or core structures for future drug development targeting iron-related death processes, such as ferroptosis. Therefore, this study will not only provide a review of the normal iron metabolism process, summarize the potential ...