We present the results of comparative ELISA of the concentration of soluble form of immunity checkpoint B7-H3 (sB7-H3) in the serum of patients with colorectal cancer (CRC) at different stages before treatment and healthy control donors. The analysis revealed a statistically significant difference ...
B7-H3 is a recently identified member of the B7 gene family. Its ubiquitous expression in both lymphoid and nonlymphoid tissues suggests that it could play an important role in the maintenance of self-tolerance. However,the exact function of B7-H3 is still elusive. The purpose of current stud...
Qijun Chen1, Chong Yang3, Bo Wang1 & Heshui Wu1 Many studies have demonstrated a relationship between soluble B7-H3 (sB7-H3) and the poor prognosis of patients with malignant tumors, and increasing evidence has shown a connection between sB7-H3 and NF-κB in tumor progression. ...
Characterization of a Soluble B7-H3 (sB7-H3) Spliced from the Intron and Analysis of sB7-H3 in the Sera of Patients with Hepatocellular Carcinoma 2013, PLoS ONE Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum...
with active AAV than in those with inactive AAV or HCs, and the surface expression of CD28 in CD4+T cells was lower in patients with high BVAS. We speculated that the shedding of surface CD28 in its soluble form acts as a regulatory mechanism that inhibits the CD27:B7 activation pathway....
The synthesis of the monomer 1,6-bis(3,6-dihexadecyl-N-carbazolyl)-2,4-hexadiyne, its polymerization and the purification of the polymer, which is soluble in common organic solvents, are reported. Results from powder X-ray diffraction studies carried out on the red form of the polymer ...
II molecules. M-MDSC has a phenotype HLA-DR−/lowCD14+, whereas MO/MA are HLA-DR+CD14+cells [7]. Although cancer cells use myriad arsenal of immunosuppressive mechanisms to escape from the host immune system, PD-L1 (also known as CD274 or B7-H1), seems to be one of the hallmarks...
Programmed death ligand 1 (PD-L1) is a cell-surface glycoprotein and a member of the B7 family of T-cell costimulatory molecules.17 Although PD-L1 mRNA is ubiquitously expressed in humans, cell-surface expression of PD-L1 is restricted to cells of the macrophage lineage.17 Of note, PD-L1...
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sB7-H3survivalThe content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that B7-H3 belongs to the immunoglobulin superfamily (B7 molecule ...