Solid-state nanopore (SSNP) or synthetic nanopore using semiconductor materials have established themselves as a single molecule bio-detection platform. Although biological nanopore with fixed dimension has been successfully utilized for many sensing applications, SSNP has unique characteristics of distinctly...
Nanopore-based sensors have established themselves as a prominent tool for solution-based, single-molecule analysis of the key building blocks of life, including nucleic acids, proteins, glycans and a large pool of biomolecules that have an essential role in life and healthcare. The predominant mo...
Fabrication and characterization of a solid state nanopore with self-aligned carbon nanoelectrodes for molecular detection G. Howitt, and R. L. Smith, "Fabrication and characterization of a solid-state nanopore with self-aligned carbon nanoelectrodes for molecular detection,"... P Spinney,SD ...
Here, we show that solid-state nanopores are well suited for fast and label-free detection of nucleosomes and its histone subcomplexes. (Nucleo-)protein complexes are individually driven through the nanopore by an applied electric field, which results in characteristic conductance blockades that ...
Single-molecular Detection of Polysaccharides with Chemically-Modified Nanopores In this work, covalently-modified solid-state nanopores (SSN) have been employed for the detection of polysaccharides with a sample concentration of 5 ng/... Y Cai,L Liang,S Wang,... - IEEE 被引量: 0发表: 2019年...
Stable fabrication of a large nanopore by controlled dielectric breakdown in a high-pH solution for the detection of various-sized molecules. Sci. Rep. 9, 13143 (2019). Article Google Scholar Zhang, Y. et al. Solid state nanopores: nanopore formation via tip-controlled local breakdown using ...
摘要: Nanopore fabrication via the controlled dielectric breakdown (CDB) method offers an opportunity to create solid-state nanopores directly in salt solution with sub-nanometer precision. Driven by trap...关键词: Controlled Dielectric Breakdown DNA Detection Lithium Chloride Nanotechnology Slowed-down ...
Nanopores have become an important tool for molecule detection at single molecular level. With the development of fabrication technology, synthesized solid-state membranes are promising candidate substrates in respect of their exceptional robustness and controllable size and shape. Here, a 30–60 (tip-...
We show that the solid-state nanopore-biosensor can detect trypsin with a limit of detection (LOD) of 0.005 ng/mL (0.2 pM). The detection system developed for the model enzyme was then applied to the detection of gingipains. The LOD for detection of gingipains was 1 ng/mL (0.02 nM), ...
There are two types of nanopore: biological and solid-state. Although biologically derived protein nanopores are ideally suited for DNA sequencing6, solid-state nanopores offer control over pore size during the fabrication process, allowing for the detection of a wide range of analytes. Although ...