Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes. By monitoring ion currents and forces as molecules pass through a solidstate nanopore, it is possible to ...
Nanopore-based sensors have established themselves as a prominent tool for solution-based, single-molecule analysis of the key building blocks of life, including nucleic acids, proteins, glycans and a large pool of biomolecules that have an essential role in life and healthcare. The predominant mol...
Here we report on label-free electrical diagnostics of influenza based on nanopore analytics that distinguishes individual virions by their distinct physical features. We accomplish selective resistive-pulse sensing of single flu virus having negative surface charges in a physiological media by exploiting...
requires an additional process before being employed as a sensor. Electrophoresis has been found to be a promising strategy that implements the trapping of the negatively charged DNA structure on a solid-state nanopore via strong electrophoretic force under an applied cross-membrane voltage. The captur...
Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes. By monitoring ion currents and forces as molecules pass through a solid-state nanopore, it is possible to ...
Solid-state nanopore (SSNP) or synthetic nanopore using semiconductor materials have established themselves as a single molecule bio-detection platform. Although biological nanopore with fixed dimension has been successfully utilized for many sensing applications, SSNP has unique characteristics of distinctly...
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In addition, we measure an unexpected double-peak ionic conductance profile. A simple model of a cylindrical nanopore that contains a nanobubble explains the measured profile and accounts for the observed variations in the magnitude of the conductance. 展开 ...
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Generally, the solid-state nanopore/nanochannel modification method is the inner wall modification, and the detection principles are the resistive pulse method and the steady-state ion current method. During the detection process, solid-state nanopore/nanochannel is easily blocked by single entities, ...