Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a pr...
England S.Voltage-gated sodium channels: the search for subtype-selective analgesics.Expert Opinion on Investigational Drugs. 2008England S. Voltage-gated sodium channels: the search for subtype-selective analgesics. Expert Opin Investig Drugs. 2008; 17 :1849–64. doi: 10.1517/13543780802514559. [ ...
网络释义 1. 电压门控钠离子通道 电压门控钠离子通道(voltage-gated sodium channels)是可兴奋细胞产生电兴奋的基础结构,其α亚单位为基本功能单位,可… www.ebiotrade.com|基于 1 个网页 2. 电压门控钠通道 电压门控通道,voltage gated... ... )voltage-gated sodium channels电压门控钠通道) voltage gated...
Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis ...
当当网图书频道在线销售正版《【预订】Voltage-Gated Sodium Channels: Structure, Function and Channelopathies》,作者:,出版社:Thames&Hudson。最新《【预订】Voltage-Gated Sodium Channels: Structure, Function and Channelopathies》简介、书评、试读、价格、图
Voltage-gated sodium channels subserve regenerative excitation throughout the nervous system, as well as in skeletal and cardiac muscle. This excitation results from a voltage-dependent mechanism that increases regeneratively and selectively the sodium conductance of the channel e-fold for a 4–7 mV...
Voltage-gated sodium channels 来自 NCBI 喜欢 0 阅读量: 42 作者:JN Wood,M Baker 摘要: Increased knowledge of the molecular diversity of sodium channel [alpha]- and [beta]-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific ...
Sodium channels x Voltage-gated sodium channels 作用机制 钠通道阻滞剂[+1] 在研机构- 原研机构 Newron Pharmaceuticals SpA 在研适应症- 非在研适应症 慢性精神分裂症[+1] 最高研发阶段无进展 首次获批国家/地区- 首次获批日期1800-01-20 26 ·
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increa