Dosing of immunoconjugates consisting of antibody and SN-38 for improvement of efficacy and reduction of toxicityThe present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to EGP-1 (TROP-2), ...
84 Furthermore, a higher E-ring stability leads to diminished bladder toxicity, one of the main problems associated to the use of camptothecin derivatives. The reason is that the relatively low pH of urine prompts the cyclization of the secreted carboxylate form, leading to the local formation ...
PURPOSE: UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity outcome of irinotecan-treated patients. We evaluated the effect of other UGT1A variants and haplotypes involved in 7-ethyl-10-hydroxycamptothecin (SN-38)... E Cecchin,F Innocenti,M D'Andrea,... - 《Journal of...
In vitro metabolic biomodulation of irinotecan to increase potency and reduce dose-limiting toxicity by inhibition of SN-38 glucuronide formation. | Crane, RA., et al. 2022. Drug Metab Pers Ther. 37: 295-303. PMID: 35257538 The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08)...
Acute toxicity, Oral (Category 3), H301 2.2 GHS Label elements, including precautionary statements Pictogram Signal word Danger Hazard statement(s)H301 Toxic if swallowed.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this p...
Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydroch... Gastrointestinal toxicity, such as late-onset diarrhea, is a significant concern in irinotecan hydrochloride (CPT-11)-containing regimens. Prophylaxi...
toxicity of the cancer prodrug, CPT-11, we have developed immunoconjugates of its active form, SN-38, and an anti-CEACAM5 antibody for targeted ... SV Govindan,TM Cardillo,SJ Moon,... - 《Clinical Cancer Research》 被引量: 94发表: 2009年 Antibody conjugates of 7-ethyl-10-hydroxycamptot...
Irinotecan (CPT-11): A preliminary investigation of the relationship between trough concentrations of the active metabolite, SN-38, and toxicity 来自 ResearchGate 喜欢 0 阅读量: 24 作者:LP Rivory,S Clarke,JF Bishop,A O'Donnell,M Findlay ...
Toxicity studies outlined the biocompatibility of the blank NPs. Increased in vitro efficacy of drug-loaded NPs compared to the free drug was confirmed by growth inhibition studies using SW-480 cell line. Additionally, the optimized NP formulation showed very promising blood circulation profile with ...
Other antibody-SN-38 immunoconjugates may show similar improved efficacy and/or decreased toxicity, compared to alternative standard therapeutic treatments, and combinations of different SN-38 immunoconjugates, or SN-38-antibody conjugates in combination with an antibody conjugated to a radionuclide, ...