human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow metastatic breast cancer (mBC) with prior endocrine therapy (ET): Primary results from DESTINY-Breast06 (DB-06). 2024 ASCO. LBA1000.
考虑到伴高度MSI或dMMR的十二指肠癌是一种罕见病,强烈建议对伴高度MSI或dMMR的十二指肠癌使用派姆单抗单药治疗。 参考文献:Nakagawa K, et al. Clinical practice guidelines for duodenal cancer 2021. J Gastroenterol. 2022 Oct 19. doi: 10.1007/s00535...
IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models[J] . Adam Carie,Jonathan Rios-Doria,Tara Costich,Brian Burke,Richard Slama,Habib Skaff,Kevin Sill,Afsaneh Lavasanifar.Journal of Drug Delivery . 2011...
Cancer ScienceBessho Y, Oguri T, Achiwa H, Muramatsu H, Maeda H, Niimi T, Sato S, Ueda R (2006) Role of ABCG2 as a biomarker for predicting resistance to CPT-11/SN-38 in lung cancer. Cancer Sci 97(3):192–198Bessho Y, Oguri T, Achiwa H, Muramatsu H, Maeda H, Niimi T, ...
In this study, we evaluated the gene expression profiles of the colon cancer cell lines treated with SN-38, the active metabolite of topoisomerase-1 inhibitor irinotecan which leads to cell cycle arrest and apoptosis. Material and Methods: The study included 3 colon cancer cell lines: KM12C, ...
In conclusion, the effect of SN-38 on the colon cancer cell lines was mediated via conducting S-phase and G2 arrest and apoptosis. This effect was found in the cell lines with higher metastatic potentials, indicating that SN-38 can be used to treat advanced colon cancers. 展开 关键词: ...
A ther- anostic micelleplex co-delivering sn-38 and vegf sirna for colorectal cancer therapy. Biomaterials 2016;86:92-105.Lee SY, Yang CY, Peng CL, et al. A theranostic micelleplex Co- delivering Sn-38 and VEGF siRNA for colorectal cancer therapy. Biomaterials. 2016;86:92-105....
WallinA.FrancisP.NilbertM.SvanvikJ.SunX. F.CHEMOTHERAPY -BASEL-Wallin A, Francis P, Nilbert M, Svanvik J, Sun XF. et al. Gene Expression Profile of Colon Cancer Cell Lines Treated with SN- 38. Chemotherapy 2010;56:17-25.
lung cancerlung adenocarcinoma7-ethyl-10-hydroxycamptothecinSN-38micellesbevacizumabIt has been demonstrated that NK012, a novel 7-ethyl-10-hydroxycamptothecin (SN-38)-incorporating polymeric micelle, exerts significantly more potent antitumor activity against various human tumor xenografts than irinotecan (...
Therefore, we aimed to determine the mechanism involved in resistance to SN38 in human cancer cells. To this end, we exposed human breast cancer MCF-7 cells to SN38 continuously and progressively and obtained cells 160-fold more resistant than the parental cells (MCF-7/SNR). Breast cancer ...