Evaluation of the clearance mechanism of non-CYP-mediated drug metabolism and DDI as a victim drug Anima Ghosal, in Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters (Second Edition), 2020 2.6 Clinical relevance and drug-drug interactions (DDI) One ...
The data corroborate that the S-phase dependent mechanism of action of topo-I inhibitors is also applicable to SN-38. The cytogenetic data indicate two distinct interactions of SN-38 with DNA: immediate induction of chromatid breaks independent from DNA synthesis, and induction of chromatid breaks...
Tissue distribution and quantitative analysis of small molecules is a key to assess the mechanism of drug action and evaluate treatment efficacy. The prodrug irinotecan (CPT-11) is widely used for chemotherapeutic treatment of colorectal cancer. CPT-11 requires conversion into its active metabolite SN...
Pharmacometabolomics reveals irinotecan mechanism of action in cancer patients. J. Clin. Pharmacol. 2019, 59, 20–34. [Google Scholar] [CrossRef] [Green Version] Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author...
临床药理学研究计划通常包含各项临床药理学研究的计划执行时间(处于临床整体研发的某个阶段)及其研究内容和目的等。在临床研发进展到不同阶段时(比如机制性验证(Proof of Mechanism, PoM)、概念性验证(Proof of Concept, PoC)和关键性临床研究)...
然后,释放的有效载荷在目标细胞(如表达特定目标抗原的细胞)中发挥作用,同时最好对非目标细胞(如不表达特定目标抗原的细胞)的影响最小化。鉴于ADC的作用机制(mechanism of action,MOA)是将有效载荷直接递送至特定位点,因此有效载荷的全身暴露可能相对低...
©1999ElsevierScienceB.V.Allrightsreserved.Keywords:Irinotecan;SN-381.Introductionalkaloid[1].CPT-11hasdemonstratedpronouncedantitumouractivityagainstalargevarietyofmalig-Irinotecan,alsoknownasCPT-11h7-ethyl-10-[4-nancies,includingcolorectalcancer,refractorycervi-(1-piperidino)-1piperidino]carbonyloxy-campto...
▪ With a device for continuous adjustment of setting current ▪ With temperature compensation ▪ With action indication ▪ With testing mechanism ▪ With stop bottom ▪ With manual and automatic reset button (NXR-200 and NXR-63...
SN-38Tissue distribution and quantitative analysis of small molecules is a key to assess the mechanism of drug action and evaluate treatment efficacy. The prodrug irinotecan (CPT-11) is widely used for...doi:10.1007/s00216-014-8237-2Achim Buck...
这里其实最好用mechanism of action of aspirin,因为mechanism后面一般接一个过程,当表达某种药物或物质的机制时,实际是说其发生作用的机制,一般用mechanism of action of。 不过当进一步问ChatGPT是mechanism of aspirin好还是mechanism of action of aspirin...