DRUG DISCOVERY : SMALL MOLECULE DRUGSApproach, IrrationalApproach, RationalApproach, Antisense
Since its foundation, Fochon Pharmaceuticals has built a significant R&D pipeline focusing on the research of innovator drugs urgently needed for clinical anti-tumor and metabolic diseases, which consists of drug candidates targeting ALK/ROS1, BCL-2, BTK, pan-TRK (1st & 2nd generation), CDK4/6...
Seven small-molecule drugs, specifically targeting the RNA polymerase and protease of 2019-nCoV are currently in clinical research, which provides insights for the research and development of antibody drugs. GUANGZHOU, Feb. 3 (Xinhua) -- While no specific remedy has been found for the novel coron...
such that each compound had at least one known cellular target (see Methods for details). The average signal of all the drug-treated wells was less than 3% different from the average of solvent-treated wells, indicating that the drugs did not...
ChemInform Abstract: Targeting RNA with Small-Molecule Drugs: Therapeutic Promise and Chemical Challenges (2001) Targeting RNA with small- molecule drugs: therapeutic promise and chemical challenges. Acc. Chem. Res. 34, 836-843. Jose,Gallego,Gabriele,... - 《Cheminform》 被引量: 422发表: 2001...
Small-molecule kinase inhibitors: an analysis of FDA- approved drugs. Drug Discov Today 2016;21:5-10.Wu P, Nielsen TE, Clausen MH. Small-molecule kinase inhibitors: An analysis ... W Peng,TE Nielsen,MH Clausen - 《Drug Discovery Today》 被引量: 118发表: 2016年 Small-molecule kinase ...
Two major classes of anti-influenza drugs currently available are admantane-based M2 protein blockers (amantadine and rimantadine) and neuraminidase (NA) inhibitors (oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of influenza A virus and the rapid emergence of resistance...
2、 Small molecule drug reprogramming indirectly regulates the expression of Yamanaka factor through small molecule drugs, so as to reprogram cells. In my introduction to rejuvenation technology, I mentioned that Harvard Medical School found that only overexpression of OSK (Oct3 / 4, Sox2, Klf4) ...
Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.
Thyroid cancer is the commonest endocrine malignancy, and drugs that target protein kinases offer a new approach in combating this and other malignancies. This review describes the various kinase targets in thyroid cancers, and details the inhibitors of