Large molecule drugs were often less defined as they were of biological origin e.g., due to posttranslational modifications and impurities. With the increasing power of analytical and preparative techniques and with the advent of molecularly exactly defined oligonucleotides , the distinction of ......
Since its foundation, Fochon Pharmaceuticals has built a significant R&D pipeline focusing on the research of innovator drugs urgently needed for clinical anti-tumor and metabolic diseases, which consists of drug candidates targeting ALK/ROS1, BCL-2, BTK, pan-TRK (1st & 2nd generation), CDK4/6...
Seven small-molecule drugs, specifically targeting the RNA polymerase and protease of 2019-nCoV are currently in clinical research, which provides insights for the research and development of antibody drugs. GUANGZHOU, Feb. 3 (Xinhua) -- While no specific remedy has been found for the novel coron...
Targeting the mitotic spindle with small-molecule drugs is a validated strategy for treating human cancers; however, collateral damage to normal cells causes myelosuppression and neurotoxicity1,2. Microtubule (MT)-targeting agents (MTAs), such as paclitaxel, activate the spindle assembly checkpoint (SA...
Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.
Thyroid cancer is the commonest endocrine malignancy, and drugs that target protein kinases offer a new approach in combating this and other malignancies. This review describes the various kinase targets in thyroid cancers, and details the inhibitors of
Currently, two main strategies against the virus are available, which are vaccination and small molecule anti-influenza drugs. Anti-influenza small molecule drugs present the first line of protection against the virus during an epidemic outbreak, especially in the early stages, as an effective ...
The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method com...
Small MoleculeDrugs No matter where you are on the path of bringing your small molecule discovery to market, DataRevive has the in-house expertise and understanding of the FDA approval methodologies needed to optimize regulatory compliance and filings, helping you bring your small molecule drug to ...
The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target...