The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducingligand), which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies....
To better promote the development of small-molecule targeted anti-cancer drugs, we will conduct a comprehensive review for them. In order to facilitate the description, protein targets of the approved agents will be taken as a clue. For each target, marketed small-molecule drugs and important dr...
In this review, we describe the current progress in small molecule-based immunomodulators (inhibitors/agonists/degraders) for cancer therapy, including those targeting PD-1/PD-L1, chemokine receptors, stimulator of interferon genes (STING), Toll-like receptor (TLR), etc. The tumorigenesis mechanism...
The hypoxic environment of solid tumours creates a hypoxia–adenosinergic axis of gene regulation, which enforces tumour immune tolerance and can be targeted by small-molecule drugs. Small-molecule immunotherapy for cancer is a growing area ripe with opportunity for exploitation of critical immune biolo...
Explore BPS Bioscience’s small molecule cancer therapy targets for advanced research in targeted treatments. Discover our range of compounds designed to inhibit key cancer-related pathways and enhance therapeutic strategies.
3.2. SW IV-134 has potent killing activity against pancreas cancer cell lines We next assessed the pharmacologic activity of our drugs on a panel of human and mouse pancreatic cancer cell lines in vitro. The cells were treated for 24 h with SW IV-134, SW43, SW IV-52, and an equimolar...
The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducingligand), which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies. DOI: 10.1038/nature.2013.12385 年份...
Cancer-proof mice live longer 2007-Jul-18 Stem cells home in on brain cancer 2004-Oct-25 Related external links Rights and permissions Reprints and permissions About this article Cite this article Cormier, Z. Small-molecule drug drives cancer cells to suicide. Nature (2013). https://doi....
Small-molecule inhibitors of both kinases have already reached the clinical testing stage. Protein kinases other than RET and BRAF are also being evaluated for their potential in thyroid-cancer treatment. Key Points Thyroid cancer is the most prevalent endocrine malignancy It is frequently associated...
To better promote the development of targeted anti-cancer drugs, we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification. We present all the approved drugs as well as important drug candidates in clinical trials for each target, discuss...