FDA-approved small-molecule kinase inhibitors. Trends Pharmacol Sci 2015; 36:422-39.Wu P, Nielsen TE, Clausen MH. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacologi- 529 cal Sciences. 2015 Jul; 36(7):422-439. http://linkinghub.elsevier.com/retrieve/pii/S0165614715000772,...
By December 2020, 89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration (NMPA) of China. Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug ...
For in silico docking, we selected two small molecule libraries: (1) currently FDA-approved small molecule drugs (~1700 compounds), and (2) ChemBridge CNS-set, a ~60,000 compound library containing drug-like compounds that have characteristics favoring brain-penetration and oral bioavailability (...
Small-molecule kinase inhibitors: an analysis of FDA-approved drugs Small-molecule kinase inhibitors (SMKIs), 28 of which are approved by the US Food and Drug Administration (FDA), have been actively pursued as promising ta... Peng,Wu,Thomas,... - 《Drug Discovery Today》 被引量: 115发表...
The advent of new small molecule therapies that act on intracellular signaling contributes to a revolution in the treatment of several dermatological diseases. Its use in inflammatory, neoplastic and even infectious diseases shows the versatility of these new therapies and is already a reality for pati...
Small MoleculeDrugs No matter where you are on the path of bringing your small molecule discovery to market, DataRevive has the in-house expertise and understanding of the FDA approval methodologies needed to optimize regulatory compliance and filings, helping you bring your small molecule drug to ...
The second is small-molecule oral drugs, including Merck's Molnupiravir and Pfizer's Paxlovid, as well as Shionogi's S-217622 (The U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for S-217622). If neutralizing antibody drugs are used to...
Small molecule inhibitors as emerging cancer therapeutics Integr Cancer Sci Ther, 1 (2014) Google Scholar [2] P. Wu, T.E. Nielsen, M.H. Clausen Small-molecule kinase inhibitors: an analysis of FDA-approved drugs Drug Discov Today, 21 (2016), pp. 5-10 View PDFView articleView in Scopus...
nitrogen and oxygen atoms in a molecule is >10. However, subsequent analysis has shown that only 51% of FDA-approved small-molecule drugs are orally administered and have followed Lipinski’s “rule of five,”[121]suggesting that otherroutes of administrationincluding parental, inhalation, dermal/...
Since single-particle cryo-EM has the advantage to reveal high resolution structures of non-crystallizable target proteins, such as membrane proteins and multi-protein complexes, more and more small molecule drugs have been and will be generated due to the advances in workflow automation ...