Bioanalytical scientists use sound scientific judgment, regulatory compliance, and project management to deliver pivotal data for project decisions in a timely manner. In this book chapter, we highlight the bioanalysis of small and large molecule drugs, metabolites, and biomarkers by LC-MS. We ...
Large Molecule Drugs Target Identification and Validation Large molecule drugs are in a separate category from small molecule drugs, which include inorganic and organic polymers (such as proteins) and biochemicals (such as polysaccharides, nucleic acids, and proteins). Large molecule drugs are most com...
Enabling protein degradation with small-molecule drugs has emerged as an innovative approach to the development of therapeutics against otherwise intractable targets. Two landmark studies that established the therapeutic potential of heterobifunctional degrader molecules are celebrating their 10-year anniversary...
Today, small molecules are commonly used as antiviral drugs, generally leading to the inhibition of some viral protein or enzyme. When we say ‘small molecule’ we are referring to molecules of a low molecular weight. Small molecules are not the only option in drug therapy. There are lots of...
The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. This article uses examples of successful discovery effort
Dr. Basil Greber discusses how he harnessed the power of cryo-EM for discovery of cancer therapeutics and details high-resolution structures of the human CDK-activating kinase bound to inhibitors. Poster: Accelerating CAK Complex Inhibitor Design through Cryo-EM ...
»Small Molecule Orphan Drugs: Status Quo, Challenges, and Perspectives Summary:The development of orphan drugs in the past year has continued to trend upwards in the US, the European Union, and Japan. This is due to the financial incentives offered through regulation, with orphan designation ...
Define Small molecule. Small molecule synonyms, Small molecule pronunciation, Small molecule translation, English dictionary definition of Small molecule. n. 1. The smallest particle of a substance that retains the chemical and physical properties of the
and other large molecule drugs due to their size, easy convertibility to oral form and, cost-effectiveness. The small molecule drug discovery market is expected to witness huge growth due to increasing approval of small molecule drugs, growing demand for R&D from contract organizations, and rising...
在单克隆抗体制备中,首先进行的就是抗原的设计与合成,这是制备单抗成功与否的关键。因为产生抗体的特异性与亲合性是与抗原密切相关的,合成的抗原如果可以将所需要的抗原决定簇充分暴露出来,那么机体更容易识别抗原决定簇,从而免疫的动物所产生的抗体自然会在特异性和亲合力上最大程度的与抗原决定 ...