Smolecule provides small-molecule compounds including inhibitors, antagonists, agonists, and modulators for biomedical and pharmaceutical research.
9 和 60 nM。它就可以抑制EGFR或VEGFR的活性，进而抑制血管的生成。
Facing the global market, Orinove upholds the concept of "grafting global resources, continuous innovation, win-win cooperation, and benefiting patients" in the R&D of original small molecule chemical drugs with new targets, first-in-class mechanisms and new structures according to international ...
Key characteristics of small molecule drugs: Size and structure: Their small size, usually between 0.1 and 1 kDa, enhances GI absorption into the bloodstream, making them suitable for oral use. Composition: These compounds are often hydrophobic and crystalline, allowing them to bypass lipid-rich ...
Definition A small molecule drug in cancer therapy is a molecularly defined chemical entity of low molecular weight, which is applied to a patient with the intention to heal or palliate primary proliferative disease . Or it is directed to prevent secondary consequences of the disease, which are ...
Marine Drugs：微藻胞外代谢物可作为新型生物肥料｜植物合成 微藻是一种微小光合生物可用作农产品生物改良...
News & Views24 Dec 2024 Nature Chemical Biology Volume: 21, P: 18-19 Targeted protein degradation comes of age Enabling protein degradation with small-molecule drugs has emerged as an innovative approach to the development of therapeutics against otherwise intractable targets. Two landmark studies...
The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. This article uses examples of successful discovery effort
10月23日,巴鲁克斯·布隆伯格研究所杰出教授Patrick Y. S. Lam应邀做客理学院第131期科学大讲堂,为我校师生分享题为“From World's Best-Selling Small-Molecule Drug (Eliquis) to a Powerful Chinese Name Reaction (Chan-Lam-C...
optimized for oral administration. Based on Lipinski’s “rule of five”[132]for orally bioavailable small-molecule drugs, poor solubility or permeability occurs when molecular mass >500Da, lipophilicity is high (calculated logP>5), there are more than five hydrogen-bond donors, and the sum of...