0:00 High resolution electron cryo-microscopy: From membrane proteins to diseases Discover how cryo-EM is impacting high resolution structure biology, from membrane proteins to diseases including Alzheimer’s disease and cancer therapeutics by showing high-resolution structures of these proteins...
For in silico docking, we selected two small molecule libraries: (1) currently FDA-approved small molecule drugs (~1700 compounds), and (2) ChemBridge CNS-set, a ~60,000 compound library containing drug-like compounds that have characteristics favoring brain-penetration and oral bioavailability (...
Small Molecule Drugs High-Value Generic Drugs Therapeutic Platform With New Technology Innovation Incubation Fosun Orinove (Suzhou)Pharma Tech, Inc. Fosun Orinove (Suzhou) PharmaTech, Inc. is an innovator drug R&D company established under the "Partnership" between Shanghai Fosun Pharmaceutical (Group)...
小分子药物(small molecule drugs)单克隆抗体制备 在单克隆抗体制备中,首先进行的就是抗原的设计与合成,这是制备单抗成功与否的关键。因为产生抗体的特异性与亲合性是与抗原密切相关的,合成的抗原如果可以将所需要的抗原决定簇充分暴露出来,那么机体更容易识别抗原决定簇,从而免疫的动物所产生的抗体自然会在特异性和亲...
Volume: 21, P: 18-19 Targeted protein degradation comes of age Enabling protein degradation with small-molecule drugs has emerged as an innovative approach to the development of therapeutics against otherwise intractable targets. Two landmark studies that established the therapeutic potential of heterobi...
Targeted drugs have emerged as a promising solution for precise cancer treatment. A common strategy is to conjugate therapeutic agents with ligands that can specifically bind to tumor cells, providing targeted therapy. Similar to the more successful antibody drug conjugates (ADCs), small molecule drug...
Structure Optimization and Identification of a Clinical Candidate Structure optimization follows two distinct courses for large molecule drugs. In the case of hormones and cytokines, where the goal is to replace or augment a naturally occurring protein, the objective is to precisely mimic and administer...
Small molecule drugs have been the mainstay of the conventional pharmaceutical industry for generations. These small molecule active pharmaceutical ingredients (APIs) can be made by organic synthesis methods or microbial fermentation. Small molecule APIs include vitamin C, steroids, and aminoglycoside and...
profile. Utilizing structure-based drug design tools, focused screening, and ADME-T innovations, Prof. LAM discovered a novel class of potent, selective, and orally bioavailable Factor Xa inhibitors culminating in Eliquis/...
Structure–activity relationship (SAR). Approach that aims to correlate the chemical structure of a compound with its biological activity. Ribonuclease-targeting chimeras (RIBOTACs). Small-molecule chimeras that activate and recruit endogenous ribonucleases to an RNA target to trigger its degradation. Gi...