Definition Cerebral small vessel ischemic disease (SVID) results from compromised functioning of the small penetrating cerebral arteries, causing reduced blood flow to deep white matter regions of the brain, leading to focal lacunar infarcts, diffuse ischemia (leukoaraiosis), vascular cognitive ...
Cerebral small vessel disease results in silent ischemic lesions (SIL) among which is leukoaraiosis. In this process, endothelial damage is probably involved. Endothelial progenitor cells (EPC), are involved in endothelial repair. By restoring the damaged endothelium, EPC could mitigate SIL and cere...
Cerebral small vessel disease can cause either ischemic stroke or intracerebral hemorrhage. Accounting for up to 25% of all strokes, it is also the second biggest contributor to the risk of dementia, and is the most common incidentally discovered finding on brain imaging. There are two main cau...
CONCLUSIONS: Cerebral small vessel disease, with or without a history of cerebrovascular disease, is associated with increased risk of death and ischemic stroke in patients with atherosclerotic disease. 展开 关键词: Humans Cerebrovascular Disorders Brain Ischemia Magnetic Resonance Imaging Risk Factors ...
Here, we show that bi-allelic NIT1 loss-of-function variants cause a genetic cerebral small vessel disease, resulting in a triad of movement disorders, massively dilated perivascular spaces on brain MRI, and fatal deep ICH. We describe the clinical phenotype, neuroimaging features, and brain vess...
Circadian Rhythms Predict Small Vessel Ischemic Disease.The author comments on the article "Cerebral small vessel disease is related to disturbed 24-h activity rhythms: A population-based study," by L. A. Zuurbier and colleagues. Topics discussed include the importance of circadian rhythm for ...
Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain? J Cereb Blood Flow Metab. 2016;36(1):143-157. doi:10.1038/jcbfm.2015.62 PubMedGoogle ScholarCrossref 6. Debette S, Strbian D, Wardlaw JM, et al; European ...
Sodium-glucose cotransporter 2 (SGLT2) and SGLT1 inhibitors may have additional beneficial metabolic effects on circulating metabolites beyond glucose regulation, which could contribute to a reduction in the burden of cerebral small vessel disease (CSVD). Accordingly, we used Mendelian Randomization (MR...
1.At present independent risk factors for coronary artery disease such as DM, small vessel, are the puzzles for PCI .[背景及意义]糖尿病(DM)合并冠心病(CHD)患者的冠状动脉多为弥漫性、不稳定病变,小血管(Small Vessle)是指直径在2。 英文短句/例句 ...
Rene´ IF de Coo6, Jan C den Hollander7, Renske Oegema1, Douglas B Gould4 and Grazia MS Mancini*,1 Familial porencephaly, leukoencephalopathy and small-vessel disease belong to the spectrum of disorders ascribed to dominant mutations in the gene encoding for type IV collagen alpha-1 (COL...