Cerebral small vessel disease is associated with an increased risk of death, ischemic stroke and cognitive decline. Changes in large artery stiffness induced by hypertension may be related to microvascular alte
SVID, small vessel ischemic disease; VaD, vascular dementia; BCCAS, bilateral common carotid artery stenosis; LOAD, late-onset Alzheimer's disease; GWAS, genome-wide association study. CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, CD2AP). They shed light on critical LOAD pathogenic path- ...
Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation. Methods: In 725 memory clinic patients with SVD (mean age 67 卤 8 years, 48% female) we compared ...
What is the prevalence of Cerebral Small Vessel Disease (CSVD) in relation to ischemic strokes and vascular dementia? What are the outcomes associated with ischemic manifestations of cerebral small-vessel disease? How do hereditary conditions contribute to the incidence of strokes attributed to Cerebral...
Patchy areas of ischemic infarction, extensive subacute and chronic hemorrhage not respecting vascular territories, encephaloclastic cysts and closed lip schizencephaly were identified. Cataract was detected postnatally. The anomalies were caused by a pathogenic mutation (c.353G>A; p.G118D) in the ...
Contrary to these results, in rodent models of ischemic injury, chronic, physiological concentrations of E2 protected the cortex againstMiddle Cerebral Artery Occlusion(MCAO)-induced damage without effecting CBF (Alkayed et al., 2000; Dubal and Wise, 2001; Rusa et al., 1999). These findings we...
Chronic daily RIC is a promising therapy for chronic neurological conditions, such as white matter disease and vascular cognitive impairment Abstract Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant organs such as the kidney, heart and brain, and represents an exciti...
Transient ischemic attack(TIA).Sometimes, a blood clot or fatty deposit can reduce or interrupt blood flow to your brain for a short time. Some people call a TIA a "ministroke." The symptoms are similar to those of a stroke, but they often resolve completely (usually within 24 hours) wi...
The involvement of the various components of the neurovascular unit is not the same in all ischemic situations. “Chronic” ischemia mainly affects the capillaries of the territories of the penetrating arteries, located in the white matter. In contrast, acute ischemia is the result of the occlusion...
Chronic: This kind of subdural bleed happens slowly, so fast treatment can lead to a better recovery. It’s usually caused by a less-serious head injury in someone who’s 65 or older, takes blood thinners, or has changes in their brain structure due todementiaor analcoholuse disorder. ...