Definition Cerebral small vessel ischemic disease (SVID) results from compromised functioning of the small penetrating cerebral arteries, causing reduced blood flow to deep white matter regions of the brain, leading to focal lacunar infarcts, diffuse ischemia (leukoaraiosis), vascular cognitive ...
We have tested whether small intraischemic variations in brain temperature influence the outcome of transient ischemia. To measure brain temperature, a thermocouple probe was placed stereotaxically into the left dorsolateral striatum of rats prior to 20 min of four-vessel occlusion. Rectal temperature ...
BACKGROUND AND PURPOSE: On cerebral magnetic resonance imaging (MRI), white matter hyperintensities (WMH) and lacunes are generally viewed as evidence of small vessel disease. The clinical significance of small vessel disease in terms of global cognitive function has as yet not been completely clarif...
Objective We hypothesized that vascular amyloid contributes to chronic brain ischemia, therefore amyloid burden measured by Pittsburgh compound B retention... ME Gurol,A Viswanathan,C Gidicsin,... - 《Annals of Neurology》 被引量: 181发表: 2013年 Cerebral white matter hyperintensities in the predic...
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among elderly individuals and is recognized as a major vascular contributor to dementia, cognitive decline, gait impairment, mood disturbance and stroke. However, clinical symptoms
are focal and multifocal confluent lesions of white matter injury that reflect axonal loss due to chronic ischemia caused by cSVD5,11,12. Studies have shown that extensive WMH burden is associated with an increased risk of incident stroke and dementia. The initial stage of cSVD is characterized ...
This can partly be explained by a lack of or a faint effect of antihypertensive therapy on the increased blood–brain barrier (BBB) permeability14, which, along with ischemia, is another significant mechanism of brain damage in hypertension15,16,17. BBB damage in patients with hypertension is ...
Like any other MRI metric, the change in white matter lesion volume cannot be considered preferable to clinical outcomes unless it has been demonstrated that it matters to the patient in terms of function. 展开 关键词: Humans Arterioles Cerebral Arteries Myelin Sheath Brain Ischemia Dementia, ...
(e.g., T cells, NK cells) were found to expand in the cerebral blood vessels, leading to inflammation, endothelial dysfunction, and ischemia in this area64. The increased expression of adhesion molecules might lead to an increased number of T cells in SHR brains. On one hand, T cells ...
Leukoaraiosis and lacunes have been recognized as aspects of cerebral small vessel diseases, while lacunes is resulted from occlusion of small arteries and leukoaraiosis is resulted from partial ischemia mainly. 目前多认为白质疏松与脑部小腔隙灶具有共同的病理基础,即脑小血管病变,脑部小腔隙主要为完全...