FDa = arteriolar fractal dimension; VRF = vascular risk factor; WMH = white matter hyperintensities; SVD = small vessel disease. Dashed lines represent non-significant associations. Full size image We tested additional SEMs—to test for co-association of retinal and SVD ...
Cerebral small vessel disease (SVD) occurs frequently in older adults, and is increasingly implicated in cognitive impairment and dementia, contributing to a significant proportion of dementia cases worldwide [1]. In fact, post-mortem studies report concomitant cerebrovascular disease in large proportions...
RCT: Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease View LargeDownload Figure 1. Study Flow Diagram View LargeDownload ISMN indicates isosorbide mononitrate. Figure 2. Cognition at 12 Months Assessed Using 7-Level Ordinal Adjusted Analysis View ...
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter hyperintensities (N = 42,310), fractional anis...
0.104% in PBS; 0.34% in HSA FLI / Monitoring thrombosis, peripheral arterial disease, tumor angiogenesis, and lymphatic drainage; imaging- guided tumor resection and sentinel lymph node biopsy Li et al.95 p-FE PS-g-PEG / 760/1,010 1.65% in water FLI / 3D vessel imaging and tumor imagin...
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white matter hyperintensities) al