Small and long non-coding RNAs: novel targets in perspective Cancer therapy. Current genomics. 2015;16(5):319-26.Han Li C, Chen Y. Small and long non-coding RNAs: Novel targets in perspective cancer therapy. Curr Genomics. 2015;16:319-326....
Long non-coding RNAs, highly expressed in the brain and expanded in mammalian genomes, provide tissue- and activity-specific epigenetic and transcriptional regulation, partly through functional control of evolutionary conserved effector small RNA activity. However, increased cognitive sophistication has ...
Non-coding RNA:a bridge betweensmall RNA and DNA. Kurth HM,Mochizuki K. RNA Biol . 2009H. M. Kurth and K. Mochizuki. Non-coding RNA: A bridge between small RNA and DNA. RNA Biol., 6:138-140, 2009.Henriette MK, Mochizuki K. Non-coding RNA: a bridge between Small RNA and DNA....
Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a ...
Long non-coding RNA LINC00525 has been reported to be upregulated in non-small cell lung cancer (NSCLC), however, its biological roles and underlying mechanism involved in modulation of NSCLC remain largely unclear. Real-time PCR were performed to determine the expression of LINC00525 and miR-...
KRAS receives and relays signals at the plasma membrane (PM) where it transmits extracellular growth factor signals to downstream effectors. SNORD50A/B were recently found to bind KRAS and inhibit its tumorigenic action by unknown mechanisms. KRAS proxim
Ruiz-Orera J, Messeguer X, Subirana J A, et al. Long non-coding RNAs as a source of new peptides[J]. elife, 2014, 3: e03523. Takahashi F, Hanada K, Kondo T, et al. Hormone-like peptides and small coding genes in plant stress signaling and development[J]. Current Opinion in ...
Numerous studies have proved that long non-coding RNAs (lncRNAs) have an important role in malignant tumors, including non-small cell lung cancer (NSCLC). LncRNA olfactory receptor family 3 subfamily A member 4 (OR3A4) was explored to identify how it functions in resistance of NSCLC patients...
Pancreatic cancer has the worst prognosis among common tumors which is attributed to its aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to systemic therapy. Non-coding RNAs (ncRNAs) such as microRNAs, long non-coding RNAs, and circular RNAs have been established as ...
The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer. Nat Genet. 2015;48:53–58. Article PubMed PubMed Central Google Scholar Su H, Xu T, Ganapathy S, Shadfan M, Long M, Huang THM, et al. Elevated snoRNA biogenesis is essential in ...