Small and long non-coding RNAs: novel targets in perspective Cancer therapy. Current genomics. 2015;16(5):319-26.Han Li C, Chen Y. Small and long non-coding RNAs: Novel targets in perspective cancer therapy. Curr Genomics. 2015;16:319-326....
Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in the mammalian brain. While the protein machinery has remained largely constant throughout animal evolution, the non protein-coding transcriptome has expanded consi
Pancreatic cancer has the worst prognosis among common tumors which is attributed to its aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to systemic therapy. Non-coding RNAs (ncRNAs) such as microRNAs, long non-coding RNAs, and circular RNAs have been established as i...
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The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer. Nat Genet. 2015;48:53–58. Article PubMed PubMed Central Google Scholar Su H, Xu T, Ganapathy S, Shadfan M, Long M, Huang THM, et al. Elevated snoRNA biogenesis is essential in ...
However, unlike miRNA fingerprints, which have been explored, the landscape of long noncoding RNAs (lncRNAs) in MSC-sEVs remains to be described. Objectives To characterize lncRNA signatures in sEVs of human adipose-derived MSCs with or without inflammatory cytokine licensing and depict MSC-sEV-...
coli is hierarchically controlled by numerous regulators among which are small noncoding RNAs (sncRNA). Results In this study, we individually deleted seventy-nine sncRNA genes from the E. coli K12-MG1655 chromosome, and established a single-sncRNA gene knockout library. By systematically screening...
Our approach for identifying any kind of sRNAs revealed enrichment of other size classes in both diatom species. Size classes including sequences that were less than 18 nt long and between 26 and 30 nt inT. pseudonanawere enriched, which was in agreement with the sRNA library band size obtaine...
Non-small cell lung cancer (NSCLC) is the major cause of cancer death worldwide. Increasing evidence shows that long non coding RNAs (lncRNAs) are widely involved in the development and progression of NSCLC. lncRNA PVT1 in several cancers has been studied, its role in lung cancer remains un...
Despite progress in treatment of small cell lung cancer (SCLC), its multidrug chemoresistance and poor prognosis still remain. Recently, we globally assessed long non-coding RNAs (lncRNAs) for contributions to SCLC chemoresistance using microarray data,