structure-function aspects of this interaction have recently been worked out in great detail[7–9]. View article Journal 1999,Cytokine & Growth Factor Reviews Related terms: Transcription Factors Eicosanoid Receptor Bone Morphogenetic Protein Kinase...
Protein Structure, Tertiaryp pIt has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily. In the ...
Smad5 gene structure and protein structure diagram. The Smad5 gene is located on human chromosome 5q31.1, with its binding region enriched with GGCGCC, GGAGCC, and GCCG sequences. The Smad5 protein comprises the MH1 and MH2 structural domains, as well as a Linker region. 1. MH1: Specifi...
Although this protein is lost in other cancers as well, loss of SMAD 4 is more sensitive and specific toPDACthan many other cancers[55]. It is inactivated in 55% ofpancreatic cancerseither by deletion of both alleles (35%) or by mutation in one allele coupled with the loss of the other...
Human SMAD3 Protein structure CAS No. Chemical Name: Human SMAD3 Protein Synonyms Human SMAD3 Protein CBNumber: CB314183758 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For QuotationSuppliers 1 ...
The Smad-interacting FYVE-domain protein SARA 45 has been suggested to act as a retention factor for Smad2 in the absence of a signal 46. This was on the basis of the observation that addition of the recombinant Smad-binding domain of SARA in a nuclear import assay inhibited nuclear import...
SMAD5 Antibody detects endogenous levels of total SMAD5 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the residues surrounding Ile251 of human SMAD5. Antibodies are purified by protein A and peptide affinity chromatography. Bone morphogenetic ...
【文献题目】Deciphering the impact of missense mutations on structure and dynamics of SMAD4 protein involved in pathogenesis of gall bladder cancer 【文献作者】Rakesh Kumar, Rahul Kumar, Pranay Tanwar, G K Rath, Ritesh Kumar, Sunil Kumar, Nihar Dash...
展开 关键词: Humans Cell Line SKP Cullin F-Box Protein Ligases RNA, Small Interfering DNA-Binding Proteins Trans-Activators Blotting, Western Precipitin Tests Signal Transduction Protein Structure, Tertiary DOI: 10.1074/jbc.C400005200 被引量: 238 年份...
binding protein with muhicing,RBPMS) 是 RNA 结合 蛋白家族的一员 ,在体外和活体 内的试验均证明它 可以与 Smad2 、Smad3 及 Smad4 结合。而 RBPMS 的 高表达可以提高 Smad 依赖性的基 因转录,反之 即 可抑 制。RBPMS 与 TGF.13R I 相 互作 用可提高 ...