T cells, based on their glycoprotein co-receptor that they have in their surface, are divided into two major CD4+and CD8+groups. CD4+T cells play an important role in the pathogenesis of IBD and CAC and divided into two groups under the names of effector cells and regulatory cells [13]....
alaevis Smad gene with or without AdML introns were amplified using PCR and inserted into the KpnI-EcoRV site of pcDNA3. laevis Smad基因有或没有AdML introns使用PCR被放大了并且被插入了入pcDNA3 KpnI-EcoRV站点。[translate] a"If you look at what he does and how he does it, I don't see ...
AIP mutations are almost always inherited from one parent; the penetrance of these mutations requires further evaluation, but seems to be very low The presence of germline MEN1 mutations should be considered a possibility in very young patients with isolated sporadic pituitary adenomas when AIP mutati...
Secretory bone morphogenetic proteins (BMP) 4, BMP8b, and BMP2 and components of the Smad signaling pathway participate in the specification of PGCs. Cells in the extraembryonic ectoderm induce expression of the gene fragilis in the epiblast in the presence of BMP4, targeting competence of PGCs....
ubiquitin chain determines whether a modified protein is degraded by the proteasome or serves to attract proteins to initiate signalling cascades or be ... D Komander - 《Biochem Soc Trans》 被引量: 902发表: 2009年 LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA...
Connective tissue growth factor (CTGF/CCN2) is a member of the CCN family of matricellular proteins. Its expression is induced by a number of factors including TGF-beta. It has been associated with fibrosis in various tissues including the kidney. Diabetic nephropathy (DN) develops in about 30...
Similarly, the onset of SSc has been associated with the presence of various polymorphisms of telomere-associated proteins, such as TERT and TERC [120]. Further research is required to understand whether the occurrence of PSVD is significantly increased in patients with rheumatologic disorders and ...
Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF-β-independent melanoma. The role for the inhibitors of differentiation (Ids) proteins in melanomagenesis has been poorly explored. In other cell types, Ids have been shown to cont... DiVito,A Kyle,Simbulan-...
Indeed, during cachexia, the selective degradation of skeletal muscle proteins, through the activation of ubiquitin–proteasome machinery, leads to the degradation of sarcomeric proteins as seen in other catabolic conditions, including muscle disuse [17,18]. Interestingly, cancer and...
Normally, NF-κB proteins are sequestered in the cytoplasm by IκB, but upon activation of various membrane receptors, like TLRs, TNFRs, and IL-1R, IκB becomes degraded, allowing NF-κB to translocate to the nucleus and act as a cofactor for the transcription of target genes [56]. ...