SMAD protein, and subsequently translocate to the nucleus where the complex directs transcription of downstream target genes.]; (ii) co-SMAD proteins [(cooperating SMAD or co-activating SMAD or C-SMAD) a term referring to a common pathway SMAD protein e.g. SMAD4 that does not become ...
SMAD protein complex assembly spermatogenesis single fertilization axon guidance endoderm development mesoderm development cell proliferation negative regulation of cell proliferation negative regulation of cardiac muscle hypertrophy positive regulation of epithelial to mesenchymal transition positive regulation of ...
SMAD protein complex assembly spermatogenesis single fertilization axon guidance endoderm development mesoderm development cell proliferation negative regulation of cell proliferation negative regulation of cardiac muscle hypertrophy positive regulation of epithelial to mesenchymal transition positive regulation of ...
pathway, SMAD protein complex assembly, regulation of mitotic cell cycle, gastrulation, mesoderm development, cell death, negative regulation of cell proliferation, regulation of cell size, activation of pro-apoptotic gene products, apoptotic mitochondrial changes, response to wounding, negative regulation ...
Tissue-specific expression of transcription factors and modification of Smad3 binding We propose a hypothesis that each Smad protein in the Smad complex binds to distinct Smad-binding sites, resulting in an assembly connecting multiple promot- er and/or enhancer regions of a target gene (Figure 5...
Smad2 ProteinSmad3 ProteinProtein interactions are critical for the function of SMADs as mediators of transforming growth factor-beta (TGF-beta) signals. TGF-beta receptor phosphorylation of SMAD2 or SMAD3 causes their association with SMAD4 and accumulation in the nucleus where the SMAD complex ...
Fig. 7: Proposed model of Smad7:β-catenin integration into the transcriptional holocomplex on theckmproximal promoter region. The coreckmpromoter proximal region contains essential binding sites for MEF2 proteins and MyoD/E protein complexes. β-catenin has also been previously implicated in binding...
We identify a mammalian forkhead domain protein, FAST2, that is required for induction of the goosecoid (gsc) promoter by TGF beta or activin signaling. FAST2 binds to a sequence in the gsc promoter, but efficient transcriptional activation and assembly of a DNA-binding complex of FAST2, Smad...
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation[J]. Nat Cell Biol,2001,3(6):587-595. 8 Lin X, Liang M, Feng XH. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta ...
DNA-templated regulation of transcription from RNA polymerase II promoter transport activation of cysteine-type endopeptidase activity involved in apoptotic process immune response cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein complex assembly endoderm development embryoni...