The TGF-β-Smad signaling pathway can also form complexes with other transcription factors such as activator protein-1 (AP-1), specificity protein 1 (SP1), Runx, etc., and regulate the expression of specific genes through their synergistic actions (Qin et al., 2018). The regulation of ...
上海博尔森生物科技有限公司生产的Smad同源物1(Smad1)重组蛋白,最新报价:2300元/μg,Smad同源物1(Smad1)重组蛋白[DESCRIPTIONDESCRIPTIONDESCRIPTIONDESCRIPTION]ProteinProteinP
full length protein 表达区域: 1-552 氨基酸序列 MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPN...
FormulationSupplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. SEQUENCES The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- WCSIAYFE MDVQVGETFK VPSSCPIVTV DGY...
Although this protein is lost in other cancers as well, loss of SMAD 4 is more sensitive and specific toPDACthan many other cancers[55]. It is inactivated in 55% ofpancreatic cancerseither by deletion of both alleles (35%) or by mutation in one allele coupled with the loss of the other...
The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. ...
In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3...
In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ...
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encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet 27:369–370 - Wakamatsu, Yamada, et al.N. Wakamatsu, et al., Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease, Nat. Genet. 27 (2001) 8 -9....