上海博尔森生物科技有限公司生产的Smad同源物1(Smad1)重组蛋白,最新报价:2300元/μg,Smad同源物1(Smad1)重组蛋白[DESCRIPTIONDESCRIPTIONDESCRIPTIONDESCRIPTION]ProteinProteinP
(Kim et al., 1997;Shi et al., 1998). While full-length Smad4 can bind DNA, it was shown that for Smad3 to bind DNA the auto-inhibitory MH1-MH2 interaction had to be relieved either through TβR-I phosphorylation or deletional removal of the MH2 domain of theSmad3 protein(...
full length protein 表达区域: 1-552 氨基酸序列 MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPN...
FormulationSupplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. SEQUENCES The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- WCSIAYFE MDVQVGETFK VPSSCPIVTV DGY...
Functional analysis in Xenopus laevis indicates that overexpression of Smad2 mimics the effects of activin, whereas overexpression of Smad1 recapitulates bone morphogenetic protein effects (3); this result suggests that different ligands selectively employ specific Smads. The primary structure of the Smads...
The type I and type II bone morphogenetic protein receptors (BMPRI and BMPRII) are present at the plasma membrane as monomers and homomeric and heteromeric complexes, which are modulated by ligand binding. The complexes of their extracellular domains with ligand were shown to form heterotetramers...
this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as ...
Cells were exposed to 500 ng/ml NCS for 1 h and then collected at the indicated time points after removal of the drug to determine the γ-H2AX protein levels. E Clonogenic formation assay to evaluate the viability levels of shCTRL and shSMAD4 cells after they were treated with NCS....
ImmunogenSMAD4 fusion protein Ag0299 Full NameSMAD family member 4 Calculated Molecular Weight60 kDa Observed Molecular Weight63-70 kDa GenBank Accession NumberBC002379 Gene SymbolSMAD4 Gene ID (NCBI)4089 RRIDAB_2193323 ConjugateUnconjugated
Interestingly, Myf5 protein in the Smad3À/À skeletal muscle was found to be downregulated.38 However, it should be considered that the differential role of TGF-b/Smad3 may be dependent on the tissue-specific context. Moreover, the detailed molecular mechanism by which TGF-b/Smad3 ...