Deer antler peptide can promote the survival and functional establishment of osteoclasts by inhibiting ferroptosis in osteoblasts, and has the potential to treat steroid-induced osteonecrosis of the femoral head, but its regulatory mechanism of ferroptosis in osteoblasts has not yet been clarif...
Key words:antler peptide,dexamethasone,steroid-induced osteonecrosis of the femoral head,inhibition,osteoblast,ferroptosis 中图分类号: R459.9 R318 R965.1 引用本文 邵学坤, 王成, 王仪, 王平, 邱卓雅, 王欣如, 孙铁锋. 鹿角多肽调控SLC7A11/GPX4轴抑制地塞米松诱导的成骨细胞铁死亡[J]. 中国组织工程研究, ...
[26] Yadav, Poonam, et al. "SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells." Cancer Letters 522 (2021): 211-224.[27] Sun, Chen, et al. "Propofol Inhibits Proliferation and Aug...
研究采用多技术联用策略:1)酶联免疫吸附试验(ELISA)定量血清GPX4/SLC7A11水平;2)免疫组化(IHC)和蛋白质印迹(Western blot)检测组织蛋白表达;3)实时定量PCR(qRT-PCR)分析mRNA水平;4)临床评估采用ARCO分期、VAS疼痛评分和HHS髋关节功能评分。 研究结果 1. 股骨头组织中GPX4和SLC7A11的局部表达 坏死区(NA)的GPX4...
[15] Koppula, Pranavi, Li Zhuang, and Boyi Gan. "Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy." Protein & cell 12.8 (2021): 599-620. [16] Iida, Yuko,et al."Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibiti...
结论 冬虫夏草能缓解放射性直肠炎,作用机制可能与调控SLC7A11、GPX4、ACSL4蛋白的表达,同时抑制炎症因子,增加机体的抗铁死亡能力相关。 [Key word] Cordyceps sinensis ; acute radiation proctitis ; ferroptosis ; glutathione peroxidase 4 (GPX4) ; mitochondrion [Abstract] Objective To investigate the efficacy ...
Figure 2: SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity
为进一步检测铁死亡是否进行HCC放射增敏,该研究使用RSL3(GPX4的抑制剂)促进铁死亡的产生,WB检测发现RSL3处理后SK-Hep-1和HepG2细胞的放射敏感性增加(图3E),而用RSL3处理siSOCS2转染的HCC细胞后,放射增敏作用随GPX4表达下降而降低(图3F,G,H,I...
Autologous fat grafting is hampered by unpredictable graft survival, which is potentially regulated by ferroptosis. Glutathione (GSH), a powerful antioxidant used in tissue preservation, has ferroptosis-regulating activity; however, its effects on fat gr
在此背景下,四川大学等机构的研究人员开展了一项极具意义的研究,相关成果发表在《Cellular and Molecular Life Sciences》杂志上。该研究聚焦于氨茶碱(Aminophylline,AMP)对 TBI 的治疗潜力,旨在揭示其是否能通过抑制神经元铁死亡(ferroptosis)来改善 TBI 患者的预后。