今天给大家分享一篇近期发表在Nature上关于靶向 SLC7A11 可改善树突状细胞的胞葬作用和糖尿病伤口愈合的文章,文章题目是Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes。该研究来自比利时根特大学的Kodi S. Ravichandran团队。其团队...
Slc7a11 was highly expressed in dendritic cells in skin, and single-cell RNA sequencing of inflamed skin showed that Slc7a11 was upregulated in innate immune cells. In a mouse model of excisional skin wounding, inhibition or loss of SLC7A11 expression accelerated healing dynamics and reduced ...
The SLC7A11 high expression group showed greater enrichment of resting NK cells, neutrophils, M0 macrophages, and activated mast cells, whereas the SLC7A11 low expression group had higher levels of resting dendritic cells, resting mast cells, and follicular helper T cells. Besides, there were ...
The CD4 T cells in cluster A were more likely to be activated, while the CD8 T cells were likely to be more prevalent in cluster B, as were dendritic cells, natural killer cells, T follicular helper cells, and type 2 T helper cells. Subsequent analysis of pathway mechanisms using GSVA ...
Document S1. Figures S1–S7 and Tables S3–S5 Table S1. Human Tconv and Treg cell gene expression matrix, related to Figures 1 and 2 Table S2. Human Tconv and Treg cell differentially expressed transcripts, related to Figssures 2 and 3 Document S2. Article plus supplemental informationVolu...
EGFR plays a multifaceted role in NPC, where it not only enhances Epstein-Barr virus (EBV) infection but also exerts its influence on cell proliferation, cycle progression, angiogenesis, invasion, and metastasis [10]. Additionally, the EGFR pathway is known to be involved in the downregulation ...
Ferroptosis is a newly discovered form of cell death characterized by intracellular iron accumulation and subsequent lipid peroxidation, which has been ide
Ferroptosis is an iron-dependent programmed cell death characterized by lipid peroxide accumulation [[1], [2], [3]]. This process is modulated by System Xc−, a cystine/glutamate antiporter in the cell membrane composed of two subunits: SLC7A11 (transports cystine and glutamate) and SLC3A2...
Cell and tissue RNA was isolated by TRIzol Reagent (Invitrogen, Carlsbad, USA). The initial cDNA synthesis using 1 μg of total RNA was achieved through the Reverse Transcription Kit (TransGen Biotech, Beijing, China). A qPCR analysis was then performed with the SYBR-Green Master Mix (TransGe...
NRF2 and the hallmarks of cancer Cancer Cell (2018) M.J.Bijlmakerset al. The on-off story of protein palmitoylation Trends Cell Biol. (2003) G.M.Thomaset al. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking ...