5. Ye J, Rawson R B, Komuro R, et al. ER stress induces cleavage of membrane-bound atf6 by the same proteases that process srebps[J].Molecular Cell, 2000, 6(6): 1355–1364. 6. Kondo Y, Fu J, Wang H,...
Site-1 protease (S1P) is a Golgi-located protein that activates unique membrane-bound latent transcription factors, and it plays an indispensable role in endoplasmic reticulum stress, lipid metabolism, inflammatory response and lysosome function. A patient with S1P mutation exhibits severe skeletal ...
Site-1 protease(S1P)是激活独特的膜结合潜伏转录因子的关键蛋白酶,被称为各种生物过程中的关键因子。有研究表明,S1P与骨骼发育有关,S1P突变患者表现出骨骼发育不良。然而,S1P在破骨形成中的作用尚不清楚。该研究表明,S1P通过ATF6/CHOP/LC3和SREBP2/LC3...
Site-1 Protease 来自 Semantic Scholar 喜欢 0 阅读量: 86 作者: NG Seidah 摘要: The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized ...
Plasmablasts generated in the presence of site-1 protease inhibitor segregated into CD38high and CD38low populations, the latter characterized by a marked reduction in the capacity to secrete IgG. Site-1 protease inhibition is accompanied by a distinctive change in gene expression associated with ...
Cell Death & Differentiationhttps://doi.org/10.1038/s41418-020-00731-6ARTICLESite-1 protease controls osteoclastogenesis by mediatingLC3 transcriptionZeyu Zheng 1,2● Xuyang Zhang 1,2 ● Bao Huang 1,2 ● Junhui Liu 1,2 ● Xiaoan Wei 1,2 ● Zhi Shan 1,2 ● Hao Wu 3 ●Zhenhua Fen...
Site-1 protease (S1P) ablation in the osterix-lineage in mice drastically reduces bone development and downregulates bone marrow-derived skeletal stem cells. Here we show that these mice also suffer from spina bifida occulta with a characteristic lack of bone fusion in the posterior neural arches...
site-1 protease|site-1 protease 基本信息 更多信息 中文名称: site-1 protease 中文同义词: 英文名称: site-1 protease 英文同义词: site-1 protease CAS号: 167140-48-9 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览site-1 protease国外供应商 中国供应商...
Baicalin promoted site‐2 protease and not site‐1 protease in endoplasmic reticulum stress‐induced apoptosis of human hepatocellular carcinoma cells Yu Z; Luo X; Wang C;.Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced ap- optosis of human ......
Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally active amino-terminal domain. PF-429242 is a potent and competitive S1P inhibitor. We here...