5. Ye J, Rawson R B, Komuro R, et al. ER stress induces cleavage of membrane-bound atf6 by the same proteases that process srebps[J].Molecular Cell, 2000, 6(6): 1355–1364. 6. Kondo Y, Fu J, Wang H,...
Site-1 protease(S1P)是激活独特的膜结合潜伏转录因子的关键蛋白酶,被称为各种生物过程中的关键因子。有研究表明,S1P与骨骼发育有关,S1P突变患者表现出骨骼发育不良。然而,S1P在破骨形成中的作用尚不清楚。该研究表明,S1P通过ATF6/CHOP/LC3和SREBP2/LC3...
Rawson RB (2013) The site-2 protease. Biochim Biophys Acta 1828:2801–2807. : 10.1016/j.bbamem.2013.03.031Rawson, R.B. (2013). The site-2 protease. Biochim Biophys Acta 1828, 2801-2807.Rawson RB (2013) The site-2 protease. Biochim Biophys Acta 1828, 2801-...
Site-1 protease (S1P) is a Golgi-located protein that activates unique membrane-bound latent transcription factors, and it plays an indispensable role in endoplasmic reticulum stress, lipid metabolism, inflammatory response and lysosome function. A patient with S1P mutation exhibits severe skeletal ...
(C) Domain structure of the human α/β-subunit precursor that is cleaved by site-1 protease (S1P) into mature and catalytically active α- and β-subunits. The luminal domain of the α-subunit contains two stealth domains, two Notch repeat-like domains, the γ-subunit binding domain, and...
Site-1 Protease 来自 Semantic Scholar 喜欢 0 阅读量: 88 作者: NG Seidah 摘要: The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized ...
Plasmablasts generated in the presence of site-1 protease inhibitor segregated into CD38high and CD38low populations, the latter characterized by a marked reduction in the capacity to secrete IgG. Site-1 protease inhibition is accompanied by a distinctive change in gene expression associated with ...
site-1 protease|site-1 protease 基本信息 更多信息 中文名称: site-1 protease 中文同义词: 英文名称: site-1 protease 英文同义词: site-1 protease CAS号: 167140-48-9 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览site-1 protease国外供应商 中国供应商...
Here, we investigated whether site-1 protease (S1P) is responsible for cleaving (P)RR to generate s(P)RR. Reduction of endogenous S1P with siRNA attenuated s(P)RR generation in Chinese hamster ovary (CHO) cells exogenously expressing human (P)RR with a C-terminal decahistidine tag [CHO/h...
Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenaviruses and therefore represents a potential target for therapy. Recently, we reported a viable hypomorphic allele of Mbtps1 (...