LNA-antisense rivals siRNA for gene silencing. Current Opinion in Drug Discovery and Development . 2004; 7 (2):188–194.JEPSEN J.S., and WENGEL J. (2004). LNA-Antisense rivals siRNA for gene silencing . Curr. Opin. Drug Discov. Devel. 7 :188–194...
DNA合成仪,RNA合成仪,LNA合成仪,核酸合成仪 英文名称:Dr.Oligo,Dr.Oligo 96,Dr.Oligo 192,ABI 3900,ABI 394,K&A H-6,H-8,H-16总访问:20650 国产/进口:进口半年访问:375 产地/品牌:美国BLP,德国K&A,OligoMaker,引物合成仪,siRNA合成仪产品类别:DNA/有机/多肽合成仪 ...
Moschos SA et al (2011) Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol Ther 19(12):2163-2168Moschos SA, Frick M, Taylor B et al.: Uptake, Efficacy, and ...
Baas, "The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence.," Methods in Molecular Biology, vol. 487, pp. 189-203, 2009.Fluiter, K.; Mook, O.R.; Baas, F. The therapeutic potential of LNA-modified siRNAs: ...
We have previously demonstrated the allele-specificity and efficiency of siRNA oligos to downregulate the expression of a mutant COL6A3 transcript in vitro. We have now extended our study to Locked Nucleic Acid (LNA)-containing antisense oligonucleotides, which are short, stable, and RNaseH-...
The 2′,4′-BNA/LNA modification in the sense strand was greatly augmented the duration of the RNAi effect, whereas cholesterol conjugation shortened the duration. Cholesterol-conjugated immunostimulatory siRNA (isRNA) induced higher serum interferon-α (IFN-α) levels than did...