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Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. Learn more For Research Use Only. Not for use in diagnostic procedures. Your choices regarding cookies on this site ...
Cryo-EM can enable you to visualize molecules across a range of sizes and can help you obtain time-critical insights for your drug discovery projects. Learn more For Research Use Only. Not for use in diagnostic procedures. Your choices regarding cookies on this site ...
Electron cryo-microscopy (cryo-EM) single-particle analysis has yielded protein structures with increasing levels of detail in recent years1,2. However, it has proved difficult to obtain cryo-EM reconstructions with sufficient resolution to visualize individual atoms in proteins. Here we use a new ...
In electron cryomicroscopy (cryo-EM), molecular images of vitrified biological samples are obtained by conventional transmission microscopy (CTEM) using large underfocuses and subsequently computationally combined into a high-resolution three-dimensional
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Since cytoskeletal polymers are difficult to crystallize, cryo-EM has been the predominant method of choice to study their structures. Recent advances in the methodology have enabled reconstructions at near-atomic resolution. In this review, we focus on novel insights gained from high-resolution cryo...
In single-particle cryo-EM, the 3D molecular structure needs to be determined from many noisy 2D tomographic projections of individual molecules, whose orientations and positions are unknown. The high level of noise and the unknown pose parameters are two key elements that make reconstruction a ...
CryoEM Processing|CryoEM 数据处理-transfer cryoSPARC single particle to RELION 单颗粒冷冻电镜数据处理中用的比较多的软件是RELION和CryoSPARC。两者各有利弊,且不同的人有不同的使用倾向。笔者认为,RELION的MotionCorr和Polish较好,而CryoSPARC的2D,Nu-refinement则较优。对于有些比较难处理的数据集,有些人会将两...
Not only has the resolution achieved in single-particle cryo-electron microscopy (cryo-EM) improved markedly, but at the same time, the number of particles needed has been reduced by a factor of 10 or more. However, not all single-particle analyses may reach atomic resolution easily, and ...