In addition, several factors that modulate the furin-transcriptional unit are being elucidated at the level of cis-acting sequences. Strategies that take advantage of the signalling pathways that regulate furin expression for the treatment of cancer will be discussed...
WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms ...
Inhibiting prorenin/prorenin receptor angiotensin system in the treatment of endometrial cancer important for endometrial cancer growth and development, either through activation of Ang II/AT1R pathways or directly, through ((P)RR) signalling. Thus... R Mohammed,SJ Delforce,W Yu,... 被引量: 0...
Mevalonate (MVA) pathway metabolites are essential for cancer cell survival and growth. Expression of the genes encoding MVA pathway enzymes is controlled by the sterol regulatory element-binding protein (SREBP) family of transcription factors. In cancer cells, oncogenic signalling pathways deregulate the...
A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis. involved in nicotine suppression; Inhibition of multiple upstream nicotine-activated pathways; Enhancement of chemoresistance in small cell lung cancer cells.Haiqi... Haiqiang,Mai,May,... - 《Journal of Biological Che...
Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF induced a significant increase in protein degradation, peaking at 4.2nM PIF (p<0.001), 'chymotrypsin-like' activity of the...
Co-Activation of TGFβ and Wnt Signalling Pathways Abrogates EMT in Ovarian Cancer Cells 来自 学术范 喜欢 0 阅读量: 31 作者:T Mitra,S Roy 摘要: BACKGROUND/AIMS: The aggressive property of ovarian cancer (OC) in terms of epithelial-mesenchymal transition (EMT), proliferation and metastasis ...
3.6. Theaflavin regulated the expression of Nrf2 signalling pathways in TCMK-1 cells To determine the potential mechanism by which theaflavin protects TCMK-1 cells exposed to H/R against oxidative stress, we first detected the expression of the Nrf2 signalling pathway in TCMK-1 cells induced by ...
Earlier studies have confirmed that green tea and its chief constituent epigallocatechin gallate (EGCG) have a potential role in the management of cancer through the modulation of cell signaling pathways. In this review, we focused on the beneficial effects of green tea and its constituents in the...
Molecular Cancer(2024) Paracrine secretion of IL8 by breast cancer stem cells promotes therapeutic resistance and metastasis of the bulk tumor cells Mingming Wu Xiao Zhang Tao Zhu Cell Communication and Signaling(2023) Regulation and signaling pathways in cancer stem cells: implications for targeted th...