In cancer cells, oncogenic signalling pathways deregulate the activity of the SREBP transcription factors and MVA pathway enzymes. Deregulated production of MVA pathway metabolites modulates multiple signalling pathways in cancer cells and contributes to transformation. Clinical trials to evaluate the utility...
3、The STING signaling pathway accounts for IFN-induced Ly6Ehi neutrophils which in-turn directly support antitumor immunity 肿瘤微环境里IFN的产生与肿瘤细胞胞浆内感应双链DNA（dsDNA）的STING信号通路激活有关，作者进一步探究了是否由于肿瘤内源性的STING通路激活导致Ly6Ehigh中性粒细胞的产生。分析4T1P和4T1M...
1、An interferon-stimulated subtype of neutrophil marks response to anti-PD1 in 4T1 breast cancer models 首先,作者用不响应抗PD1治疗的乳腺癌细胞系4T1(4T1P)构建了突变的可应答该治疗的细胞系(4T1M),然后将其注射到BALBc小鼠成瘤,即为后续使用的动物模型(图1A)。实验验证结果表明,4T1M具有更高的免疫原...
DOD Breast Cancer Research Program-Era of Hope Scholar Award Research Interests: We are interested in the molecular mechanisms that control genomic stability, tumor suppression and longevity. Genomic instability is a common feature of all human cancers. The maintenance of genomic integrity following DNA...
Activating cGAS/STING generates type 1 IFN, which may prevent cellular transformation and cancer development, growth, and metastasis. The current article delineates the impact of the cancer cell-specific cGAS/STING signaling pathway alteration in tumors and its impact on tumor growth and metastasis. ...
The mitogen-activated protein kinase (MAPK) pathway mediates signal transduction from cell surface receptors to downstream transcription factors that lead to cellular responses such as cell proliferation, growth, motility, survival and apoptosis. The role of MAPK pathway in cancer, immune disorders and ...
signaling pathways, combined with DNA-damaging chemotherapy, we report that time-staggered EGFR inhibition, but not simultaneous coadministration, dramatically sensitizes a subset of triple-negative breast cancer cells to genotoxic drugs. Systems-level analysisusing high-density time-dependent measurements ...
New Signaling Pathway That Controls Cell Development And Cancer
The mitogen-activated protein kinase (MAPK) pathway mediates signal transduction from cell surface receptors to downstream transcription factors that lead to cellular responses such as cell proliferation, growth, motility, survival and apoptosis. The role of MAPK pathway in cancer, immune disorders and ...
Functional annotation of the Hippo pathway somatic mutations in human cancers The Hippo signalling pathway is commonly mutated across cancer types. Here, the authors identify 85 loss-of-function missense mutations within Hippo signalling genes and highlight the mechanisms underpinning mutations in MOB1 ...