Sickle cell disease is a common and life-threatening haematological disorder that affects millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in small vessels, and this vaso-occlusion leads to distal tissue ischaemia and inflammation, with symptoms defining the acute ...
Sickle-cell disease is a chronic disease with acute and often life-threatening complications that frequently bring patients to the emergency department (ED). The clinical phenotype of sickle-cell disease varies widely and is characterized by anemia, severe pain, and potentially life-threatening ...
Sickle cell disease is an inherited, chronic condition in which the red blood cells, which are normally disc shaped, become crescent shaped. As a result, the red blood cells function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called “sickle cell...
Australasian Medical Publishing Co. Pty Ltd. (AMPCo)The Medical Journal of AustraliaStokes IC, Downie PA, Wood EM, Bowden DK, Monagle PT, Barnes CD. Hyperhaemolysis in sickle cell disease--an unusual and potentially life-threatening complication. Med J Aust 2010;192:281-2....
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Haemoglobin molecules that include mutant ...
About sickle cell disease Sickle cell disease is a debilitating, life-threatening group of rare, inherited red blood cell disorders caused by a mutation in the haemoglobin gene within red blood cells2,3. This mutatio...
Fever is one of the principalreasons for the hospitalization of children afflicted by major sickle-celldisorder, since it can be a clinical reflection of severe infections that havethe potential to become life threatening. Objectives: Identification of the main causes offever in children with SCD ...
Sickle cell disease or sickle cell anemia is the most common of the hereditary blood disorders among black people of African descent worldwide. Learn about symptoms, treatment, causes, inheritance, testing, complications, and more.
PRIMER Sickle cell disease Gregory J. Kato1, Frédéric B. Piel2, Clarice D. Reid3, Marilyn H. Gaston4, Kwaku Ohene‑Frempong5, Lakshmanan Krishnamurti6, Wally R. Smith7, Julie A. Panepinto8, David J. Weatherall9, Fernando F. Costa10 and Elliott P. Vichin...
People with sickle cell disease -- a genetic blood disorder predominantly found in Black people -- are 6.2 times more likely to die from COVID-19 than the general Black population of the United States, one study found. "Sickle cell disease patients should be aware that they are a high-ris...