AS we commemorate World Sickle Cell Day on June 19 every year, we create awareness about the clutches of the deadly Sickle Cell Disease, SCD, a disease that has brought untold hardships and misery upon many families, a disease that has stolen the joy from the childhood of many childr...
Four years after being functionally cured of sickle cell disease with a CRISPR gene-editing therapy,Jimi Olagherehas set a new world record for patients with this chronic and deadly disease. Olaghere, a 39-year-old business owner from Atlanta, became the world’s first patient with sic...
(Figure 2). Anthony Allison, an internist and epidemiologist working in Kenya, wondered how thismutantgene, which causes a deadly disease when present in two copies, could have reached such high levels in certain populations while being nearly nonexistent in other African populations (Allison, ...
Sickle cell diseaseSickle cell traitsOxidative stressComplicationsSickle cell disease (SCD) is commonly dreaded by many while sickle cell trait (SCT) is usually not seen as anything deadly even though the same, or even worse, complications may be seen with the latter under certain conditions ...
relievers whenever I can’t bear the pain. I make sure I drink plenty water, rest and always tell myself that I would be fine. This mentality has been helping me to cope with sickle cell disease even though sometimes I feel down, depressed and wish I never had this deadly disease. ...
Complications of Sickle Cell Disease This disease can lead to strokes, high blood pressure in your lungs, organ damage, leg ulcers, blindness, and gallstones. Sickle cell can also cause acute chest syndrome, a potentially deadly condition that involves chest pain, fever, cough, and a hard time...
We describe a case of renal papillary necrosis in a middle-aged female with sickle cell trait who presented with gross hematuria. We wish to highlight this case for several reasons. Sickle cell trait is often viewed as a benign condition despite the fact that it is associated with significant...
The polymerization of sickle cell hemoglobin (HbS) in the erythrocytes of sickle cell anemia patients is the primary event in the pathophysiology of this debilitating and deadly disease. Correspondingly, the majority of the current clinical treatments rely on delaying HbS polymerization. In search of ...
sickle cell disease was the 12th leading cause of death globally for children under the age of 5 years. However, total sickle cell disease mortality burden was
A new study shows how chronic psychological stress leads to painful vessel-clogging episodes—the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome pla